Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 13/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14237635 | 0.91 | NPC1 (0.33) | KDM4ENPC1S1PR4ALDH1A1HSP90AA1 | |
| SCHEMBL14237295 | 0.90 | GPR119 (0.38) | GPR119KDM1ACHRM2CHRM5CHRM1 | |
| SCHEMBL14237366 | 0.90 | GPR119 (0.36) | GPR119KDM1ACHRM2CHRM5CHRM1 | |
| SCHEMBL14237490 | 0.87 | GPR119 (0.42) | GPR119KDM1ANR3C2 | |
| SCHEMBL14237370 | 0.87 | NPC1 (0.40) | KDM4ENPC1S1PR4ALDH1A1HSP90AA1 | |
| SCHEMBL1550309 | 0.86 | GPR119 (0.43) | GPR119KDM1ANR3C2 | |
| SCHEMBL14237358 | 0.85 | GPR119 (0.39) | GPR119KDM4ENPC1S1PR4ALDH1A1 | |
| SCHEMBL14237555 | 0.85 | CHEK1 (0.34) | GPR119KDM4ENPC1S1PR4ALDH1A1 | |
| SCHEMBL14237588 | 0.84 | MAPT (0.35) | KDM4ENPC1S1PR4ALDH1A1HSP90AA1 | |
| SCHEMBL14237714 | 0.83 | GPR6 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313395-B1 | PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2012-12-19 | — | — | EP | claimed |