Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 12/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14237689 | 0.90 | GPR119 (0.37) | GPR119KDM1ACHRM2CHRM5CHRM1 | |
| SCHEMBL14237295 | 0.88 | GPR119 (0.38) | GPR119KDM1ACHRM2CHRM5CHRM1 | |
| SCHEMBL2544231 | 0.86 | GPR119 (0.42) | GPR119KDM1ATBK1 | |
| SCHEMBL14237704 | 0.84 | KCNH2 (0.36) | — | |
| SCHEMBL2542952 | 0.82 | GPR119 (0.48) | GPR119JAK2TBK1 | |
| SCHEMBL14237635 | 0.81 | NPC1 (0.33) | — | |
| SCHEMBL2457907 | 0.81 | GPR119 (0.45) | GPR119KDM1ACHRM2CHRM5CHRM1 | |
| SCHEMBL2458138 | 0.79 | GPR119 (0.41) | GPR119KDM1ACHRM2CHRM5CHRM1 | |
| SCHEMBL14237490 | 0.78 | GPR119 (0.42) | GPR119KDM1A | |
| SCHEMBL14237370 | 0.77 | NPC1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313395-B1 | PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2012-12-19 | — | — | EP | claimed |