Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14239050 | 0.89 | RAB9A (0.40) | RAB9ANPC1SMN1; SMN2LMNACYP1A2 | |
| SCHEMBL6921870 | 0.88 | RAB9A (0.40) | RAB9ANPC1SMN1; SMN2LMNACYP1A2 | |
| SCHEMBL14239358 | 0.88 | RAB9A (0.44) | RAB9ANPC1SMN1; SMN2LMNACYP1A2 | |
| SCHEMBL14239051 | 0.85 | RAB9A (0.40) | RAB9ANPC1SMN1; SMN2LMNACYP1A2 | |
| SCHEMBL14238938 | 0.84 | GRM2 (0.42) | CYP11B2CYP11B1DYRK1AGSK3BCYP1A2 | |
| SCHEMBL14239808 | 0.84 | RAB9A (0.41) | RAB9ANPC1SMN1; SMN2LMNACYP1A2 | |
| SCHEMBL14239054 | 0.83 | RAB9A (0.37) | RAB9ANPC1SMN1; SMN2LMNACYP1A2 | |
| SCHEMBL15818303 | 0.83 | GRM5 (0.46) | RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL14239353 | 0.82 | CYP3A4 (0.41) | RAB9ANPC1SMN1; SMN2LMNACYP1A2 | |
| SCHEMBL14239132 | 0.82 | ALDH1A1 (0.44) | RAB9ANPC1SMN1; SMN2LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012170845-A2 | METABOTROPIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF | HEFFERNAN MICHELE L R (US) | 2012-12-13 | — | — | WO | disclosed |