Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 8/20 | 0.48 |
| ▸ | AXL | P30530 | 2/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | INSR | P06213 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | ROS1 | P08922 | 2/20 | 0.40 |
| ▸ | FER | P16591 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20093329 | 0.88 | CDK8 (0.46) | CDK8AXLMETKDRFGFR1 | |
| SCHEMBL410659 | 0.83 | CDK8 (0.52) | CDK8AXLMETKDRFGFR1 | |
| SCHEMBL7999752 | 0.82 | ULK1 (0.43) | CDK8AXLMETKDRFGFR1 | |
| SCHEMBL14833681 | 0.81 | CDK8 (0.48) | CDK8AXLMETKDRFGFR1 | |
| SCHEMBL8738132 | 0.81 | CDK8 (0.73) | CDK8AXLKDRPIK3CDPIK3CA | |
| SCHEMBL18745812 | 0.80 | CDK8 (0.50) | CDK8AXLMETKDRFGFR1 | |
| SCHEMBL6845179 | 0.80 | CDK8 (0.50) | CDK8AXLMETKDRFGFR1 | |
| SCHEMBL22078578 | 0.80 | CDK8 (0.50) | CDK8AXLMETKDRFGFR1 | |
| SCHEMBL4562745 | 0.80 | CDK8 (0.65) | CDK8AXLMETKDRFGFR1 | |
| Hydrochloric Acid SCHEMBL12984493 | 0.79 | CDK8 (0.49) | CDK8AXLMETKDRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11318134-B2 | Benzamide compounds | RECURIUM IP HOLDINGS, LLC (US) | 2022-05-03 | — | — | US | disclosed |
| US-20210393608-A1 | SUBSTITUTED INDOLE DIMER COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2021-12-23 | — | — | US | disclosed |
| US-20210315894-A9 | 4,6-PYRIMIDINYLENE DERIVATIVES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-10-14 | — | — | US | disclosed |
| US-20200338071-A1 | BENZAMIDE COMPOUNDS | ZENO MANAGEMENT, INC. | 2020-10-29 | — | — | US | disclosed |
| US-20200339605-A1 | BENZAMIDE COMPOUNDS | ZENO MANAGEMENT, INC. | 2020-10-29 | — | — | US | disclosed |
| US-20200338075-A1 | 4,6-PYRIMIDINYLENE DERIVATIVES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-10-29 | — | — | US | disclosed |
| US-20120309963-A1 | 5-CYANO-4- (PYRROLO [2,3B] PYRIDINE-3-YL) -PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200338075-A1 | 4,6-PYRIMIDINYLENE DERIVATIVES AND USES THEREOF | CDK3, CDK1, CDK14 | CDK8 23/4885AXL 1891/4885MET 3700/4885 |
| US-20210393608-A1 | SUBSTITUTED INDOLE DIMER COMPOUNDS | TLR7, TLR9, NOD2 | CDK8 303/4885AXL 1495/4885MET 2773/4885 |
| US-20210315894-A9 | 4,6-PYRIMIDINYLENE DERIVATIVES AND USES THEREOF | CDK3, CDK1, CDK14 | CDK8 23/4885AXL 1891/4885MET 3700/4885 |
| US-11318134-B2 | Benzamide compounds | MKI67, TMBIM6, HDAC1 | CDK8 290/4885AXL 4123/4885MET 4103/4885 |
| US-20200339605-A1 | BENZAMIDE COMPOUNDS | MKI67, TMBIM6, HDAC1 | CDK8 290/4885AXL 4123/4885MET 4103/4885 |
| US-20200338071-A1 | BENZAMIDE COMPOUNDS | MKI67, TMBIM6, HDAC1 | CDK8 290/4885AXL 4123/4885MET 4103/4885 |
| US-20120309963-A1 | 5-CYANO-4- (PYRROLO [2,3B] PYRIDINE-3-YL) -PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | MAP3K5, CDK5, MAP4K2 | CDK8 172/4885AXL 679/4885MET 2724/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.