SCHEMBL14239349

SCHEMBL14239349

CCC1(F)CCc2nc3cc(-c4ccccn4)ccc3c(=O)n2CC1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 4/20 0.42
RAB9A P51151 4/20 0.42
TDP1 Q9NUW8 2/20 0.42
NSD2 O96028 1/20 0.41
L3MBTL1 Q9Y468 3/20 0.39
ALDH1A1 P00352 2/20 0.39
KDM4E B2RXH2 1/20 0.39
USP2 O75604 1/20 0.39
CYP1A2 P05177 1/20 0.39
BCHE P06276 1/20 0.39
CFTR P13569 1/20 0.39
ALOX15 P16050 1/20 0.39
ACHE P22303 1/20 0.39
HKDC1 Q2TB90 1/20 0.39
HSD17B10 Q99714 1/20 0.39
GOPC Q9HD26 1/20 0.39
CYP3A4 P08684 1/20 0.38
METAP2 P50579 1/20 0.38
POLB P06746 2/20 0.38
MEN1 O00255 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6920819 0.88 RAB9A (0.43) NPC1RAB9ATDP1NSD2L3MBTL1
SCHEMBL6922423 0.88 NPC1 (0.45) NPC1RAB9ATDP1NSD2L3MBTL1
SCHEMBL14239351 0.88 METAP2 (0.35) NPC1RAB9ATDP1NSD2L3MBTL1
SCHEMBL6922846 0.86 RAB9A (0.45) NPC1RAB9ATDP1NSD2L3MBTL1
SCHEMBL6921104 0.85 RAB9A (0.46) NPC1RAB9ATDP1NSD2L3MBTL1
SCHEMBL6920966 0.85 NPC1 (0.46) NPC1RAB9ATDP1NSD2L3MBTL1
SCHEMBL6922046 0.84 NPC1 (0.42) NPC1RAB9ATDP1NSD2L3MBTL1
SCHEMBL14238863 0.83 NPC1 (0.40) NPC1RAB9ATDP1NSD2L3MBTL1
SCHEMBL6922494 0.83 NPC1 (0.42) NPC1RAB9ATDP1NSD2L3MBTL1
SCHEMBL14238965 0.82 NPC1 (0.39) NPC1RAB9ATDP1NSD2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012170845-A2 METABOTROPIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF HEFFERNAN MICHELE L R (US) 2012-12-13 WO disclosed