SCHEMBL14239394

SCHEMBL14239394

COC(=O)Cc1ccc(C(=O)O)c(N)c1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.67
GAA P10253 3/20 0.67
GFER P55789 1/20 0.67
SLC7A5 Q01650 1/20 0.48
CYP4F2 P78329 1/20 0.47
CYP4A11 Q02928 1/20 0.47
HSP90AB1 P08238 1/20 0.46
CDC25B P30305 1/20 0.45
CASP6 P55212 1/20 0.45
RCE1 Q9Y256 1/20 0.45
HPGD P15428 5/20 0.44
KDM4E B2RXH2 4/20 0.44
MAPT P10636 3/20 0.44
HSD17B10 Q99714 3/20 0.44
TSHR P16473 2/20 0.44
ALOX15 P16050 2/20 0.44
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
PKM P14618 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28629032 0.83 ALDH1A1 (0.47) ALDH1A1GAAGFERSLC7A5CDC25B
SCHEMBL7237331 0.83 ALDH1A1 (0.75) ALDH1A1GAAGFERSLC7A5CYP4F2
SCHEMBL30565426 0.83 ALDH1A1 (0.75) ALDH1A1GAAGFERSLC7A5CYP4F2
SCHEMBL24410145 0.82 ALDH1A1 (0.51) ALDH1A1GAAGFERSLC7A5CYP4F2
SCHEMBL30965002 0.82 ALDH1A1 (0.51) ALDH1A1GAAGFERSLC7A5CYP4F2
SCHEMBL8147823 0.80 ALDH1A1 (0.71) ALDH1A1GAAGFERSLC7A5CYP4F2
SCHEMBL20045098 0.80 ALDH1A1 (0.71) ALDH1A1GAAGFERSLC7A5CYP4F2
SCHEMBL287469 0.80 GAA (1.00) ALDH1A1GAAGFERSLC7A5CYP4F2
SCHEMBL7247237 0.79 ALDH1A1 (0.69) ALDH1A1GAAGFERSLC7A5CYP4F2
SCHEMBL5734658 0.79 ALDH1A1 (0.69) ALDH1A1GAAGFERSLC7A5CYP4F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012170845-A2 METABOTROPIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF HEFFERNAN MICHELE L R (US) 2012-12-13 WO disclosed