Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14239665 | 0.86 | KDM4E (0.51) | MAPTKDM4ETHRBGPR119IGF1R | |
| SCHEMBL15535113 | 0.85 | KDM4E (0.50) | MAPTKDM4ETHRBGPR119MEN1 | |
| SCHEMBL14240506 | 0.84 | IGF1R (0.49) | MAPTKDM4ETHRBGPR119KMT2A | |
| SCHEMBL15534854 | 0.82 | KDM4E (0.54) | MAPTKDM4ETHRBGPR119MEN1 | |
| SCHEMBL15641234 | 0.81 | KDM4E (0.50) | MAPTKDM4ETHRBGPR119MEN1 | |
| SCHEMBL25165955 | 0.80 | ALDH1A1 (0.53) | MAPTKDM4ETHRBGPR119STS | |
| SCHEMBL16220348 | 0.79 | KDM4E (0.52) | MAPTKDM4ETHRBGPR119MEN1 | |
| SCHEMBL25719736 | 0.79 | GPR119 (0.51) | MAPTKDM4ETHRBGPR119 | |
| SCHEMBL21606956 | 0.79 | GPR119 (0.50) | GPR119 | |
| SCHEMBL16220400 | 0.78 | KDM4E (0.43) | MAPTKDM4ETHRBGPR119MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2719696-A1 | NOVEL KINASE INHIBITORS | Asinex Limited (RU) | 2014-04-16 | — | — | EP | disclosed |
| WO-2012169934-A1 | NOVEL KINASE INHIBITORS | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "АСИНЭКС МЕДХИМ" (RU) | 2012-12-13 | — | — | WO | disclosed |