Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.44 |
| ▸ | KCNN3 | Q9UGI6 | 12/20 | 0.38 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.36 |
| ▸ | KCNN2 | Q9H2S1 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14242606 | 0.85 | PDE10A (0.42) | PDE10AKCNN3KCNN1KCNN2HSP90AA1 | |
| SCHEMBL2027726 | 0.83 | PDE10A (0.40) | PDE10AKCNN3KCNN1KCNN2MEN1 | |
| SCHEMBL14158263 | 0.82 | PDE10A (0.51) | PDE10AKCNN3KCNN1KCNN2MEN1 | |
| SCHEMBL5440050 | 0.81 | PDE10A (0.39) | PDE10AKCNN3KCNN1KCNN2MEN1 | |
| SCHEMBL13117303 | 0.80 | PDE10A (0.38) | PDE10AKCNN3KCNN1KCNN2PCSK9 | |
| SCHEMBL14242530 | 0.80 | PAX8 (0.37) | MEN1KMT2APAX8 | |
| SCHEMBL1934777 | 0.79 | PDE10A (0.36) | PDE10AKCNN3KCNN1KCNN2HSP90AA1 | |
| SCHEMBL1487759 | 0.78 | PDE10A (0.36) | PDE10AKCNN3HSP90AA1HSP90AB1 | |
| SCHEMBL13777950 | 0.78 | ALDH1A1 (0.40) | PDE10AKCNN3MEN1KMT2A | |
| SCHEMBL13778080 | 0.78 | PDE10A (0.38) | PDE10AKCNN3MEN1KMT2APCSK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012170827-A2 | PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS CK2 INHIBITORS | CYLENE PHARMACEUTICALS, INC. (US) | 2012-12-13 | — | — | WO | disclosed |