Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | PRKACA | P17612 | 1/20 | 0.30 |
| ▸ | LTK | P29376 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14242607 | 0.87 | USP30 (0.36) | FLT3NR1H2 | |
| SCHEMBL14158143 | 0.84 | KMT2A (0.38) | KMT2AMEN1NPC1RXFP1ATM | |
| SCHEMBL14242529 | 0.80 | PDE10A (0.44) | PAX8KMT2AMEN1 | |
| SCHEMBL14158109 | 0.79 | ABCB1 (0.36) | KMT2AMEN1NPC1RXFP1MAPK8 | |
| SCHEMBL14243307 | 0.77 | PAX8 (0.32) | PAX8IRAK4 | |
| SCHEMBL14158414 | 0.71 | PDE10A (0.36) | KMT2AMEN1NPC1RXFP1ATM | |
| SCHEMBL1527844 | 0.71 | GPR119 (0.36) | — | |
| SCHEMBL14158351 | 0.69 | PDE10A (0.54) | KMT2AMEN1NPC1RXFP1ATM | |
| SCHEMBL21248469 | 0.67 | BRD4 (0.38) | PAX8IRAK4KMT2AMEN1NPC1 | |
| SCHEMBL5446935 | 0.67 | HTR1D (0.37) | PAX8KMT2AMEN1MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012170827-A2 | PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS CK2 INHIBITORS | CYLENE PHARMACEUTICALS, INC. (US) | 2012-12-13 | — | — | WO | disclosed |