Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 4/20 | 0.36 |
| ▸ | JAK1 | P23458 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | USP19 | O94966 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26705610 | 0.82 | RORC (0.39) | RORCRAB9AJAK2JAK1CYP2D6 | |
| SCHEMBL26705603 | 0.80 | RAB9A (0.40) | RORCRAB9AJAK2JAK1CYP2D6 | |
| SCHEMBL3663186 | 0.78 | CYP2D6 (0.42) | RORCRAB9AJAK2JAK1CYP2D6 | |
| SCHEMBL19158943 | 0.78 | CYP2D6 (0.45) | RORCRAB9ACYP2D6MEN1HPGD | |
| SCHEMBL18932497 | 0.77 | RAB9A (0.40) | RORCRAB9AJAK2JAK1CYP2D6 | |
| SCHEMBL6800227 | 0.76 | USP2 (0.42) | HPGDHDAC2 | |
| SCHEMBL1127578 | 0.73 | GAA (0.39) | RORCRAB9AJAK2JAK1CYP2D6 | |
| SCHEMBL4008393 | 0.73 | RAB9A (0.41) | RORCRAB9AJAK2JAK1MEN1 | |
| SCHEMBL18177265 | 0.72 | OPRD1 (0.40) | CYP2D6CYP1A2CYP2C9 | |
| SCHEMBL3714096 | 0.72 | RAB9A (0.38) | RORCRAB9AJAK2JAK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2721016-A1 | TRPV4 ANTAGONISTS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2014-04-23 | — | — | EP | disclosed |
| EP-2720546-A1 | TRPV4 ANTAGONISTS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2014-04-23 | — | — | EP | disclosed |
| WO-2013012500-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2013-01-24 | — | — | WO | disclosed |
| WO-2012174342-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2012-12-20 | — | — | WO | disclosed |