Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 10/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14247506 | 0.91 | TLR8 (0.46) | NPSR1POLBMAPTMAPK1L3MBTL1 | |
| SCHEMBL14247511 | 0.89 | ALOX15 (0.53) | POLBMAPTMAPK1L3MBTL1KMT2A | |
| SCHEMBL14247585 | 0.89 | HTR7 (0.49) | NPSR1POLBMAPTMAPK1KMT2A | |
| SCHEMBL14247213 | 0.88 | KMT2A (0.41) | NPSR1POLBMAPTMAPK1L3MBTL1 | |
| SCHEMBL14247277 | 0.86 | KMT2A (0.39) | NPSR1POLBMAPTMAPK1L3MBTL1 | |
| SCHEMBL18732121 | 0.83 | LMNA (0.51) | NPSR1POLBMAPTMAPK1L3MBTL1 | |
| SCHEMBL14247207 | 0.83 | ALOX15 (0.47) | MAPK1KMT2ATLR8ALOX15CXCR4 | |
| SCHEMBL14247475 | 0.81 | TLR8 (0.44) | POLBMAPK1KMT2ATLR8ALOX15 | |
| SCHEMBL14247793 | 0.80 | TLR8 (0.43) | MAPK1KMT2ATLR8ALOX15CXCR4 | |
| SCHEMBL3400537 | 0.80 | CXCR4 (0.66) | NPSR1POLBMAPTKMT2ATLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012174312-A2 | BENZIMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-12-20 | — | — | WO | disclosed |
| WO-2012174312-A2 | BENZIMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-12-20 | — | — | WO | disclosed |