Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A2 | P43004 | 2/20 | 0.50 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.50 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.50 |
| ▸ | METAP1 | P53582 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 3/20 | 0.47 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.45 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.44 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.44 |
| ▸ | FAP | Q12884 | 1/20 | 0.44 |
| ▸ | GSR | P00390 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 3/20 | 0.44 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Norleucine SCHEMBL28461745 | 0.88 | SLC1A2 (0.49) | SLC1A2SLC1A1SLC1A3METAP1DPP4 | |
| Norleucine SCHEMBL29557418 | 0.85 | METAP1 (0.51) | SLC1A2SLC1A1SLC1A3METAP1DPP4 | |
| Norleucine SCHEMBL14935842 | 0.85 | METAP1 (0.51) | SLC1A2SLC1A1SLC1A3METAP1DPP4 | |
| Norleucine SCHEMBL2785913 | 0.83 | SLC1A2 (0.67) | SLC1A2SLC1A1SLC1A3DDAH1GRIK1 | |
| Norleucine SCHEMBL26474 | 0.83 | SLC1A2 (0.67) | SLC1A2SLC1A1SLC1A3DDAH1GRIK1 | |
| Norleucine SCHEMBL5497693 | 0.83 | SLC1A2 (0.67) | SLC1A2SLC1A1SLC1A3DDAH1GRIK1 | |
| Norleucine SCHEMBL198127 | 0.83 | — | — | |
| Norleucine SCHEMBL8392 | 0.83 | — | — | |
| Norleucine SCHEMBL5051846 | 0.83 | SLC1A2 (0.67) | SLC1A2SLC1A1SLC1A3DDAH1GRIK1 | |
| Norleucine SCHEMBL8393 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3769776-A1 | PEPTIDOMIMETIC MACROCYCLES | Aileron Therapeutics, Inc. (US) | 2021-01-27 | — | — | EP | disclosed |
| EP-2822572-B1 | PEPTIDOMIMETIC MACROCYCLES | AILERON THERAPEUTICS INC (US) | 2020-06-10 | — | — | EP | disclosed |
| EP-3432904-A2 | COMPANION DIAGNOSTIC TOOL FOR PEPTIDOMIMETIC MACROCYCLES | Aileron Therapeutics, Inc. (US) | 2019-01-30 | — | — | EP | disclosed |
| WO-2018165575-A2 | WARHEAD-CONTAINING PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF BFL-1 | AILERON THERAPEUTICS, INC. (US) | 2018-09-13 | — | — | WO | disclosed |
| EP-3347372-A1 | PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF MCL-1 | Aileron Therapeutics, Inc. (US) | 2018-07-18 | — | — | EP | disclosed |
| EP-3294318-A1 | PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF | Aileron Therapeutics, Inc. (US) | 2018-03-21 | — | — | EP | disclosed |
| WO-2017165299-A2 | COMPANION DIAGNOSTIC TOOL FOR PEPTIDOMIMETIC MACROCYCLES | AILERON THERAPEUTICS, INC. (US) | 2017-09-28 | — | — | WO | disclosed |
| EP-3197478-A1 | PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF | Aileron Therapeutics, Inc. (US) | 2017-08-02 | — | — | EP | disclosed |
| EP-3197477-A1 | PEPTIDOMIMETIC MACROCYCLES AND FORMULATIONS THEREOF | Aileron Therapeutics, Inc. (US) | 2017-08-02 | — | — | EP | disclosed |
| WO-2017044633-A1 | PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF MCL-1 | AILERON THERAPEUTICS, INC. (US) | 2017-03-16 | — | — | WO | disclosed |
| WO-2016049355-A1 | PEPTIDOMIMETIC MACROCYCLES AND FORMULATIONS THEREOF | AILERON THERAPEUTICS, INC. (US) | 2016-03-31 | — | — | WO | disclosed |
| WO-2016049359-A1 | PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF | AILERON THERAPEUTICS, INC. (US) | 2016-03-31 | — | — | WO | disclosed |
| EP-2822572-A1 | PEPTIDOMIMETIC MACROCYCLES | Aileron Therapeutics, Inc. (US) | 2015-01-14 | — | — | EP | disclosed |
| EP-2819688-A1 | TRIAZOLE-CROSSLINKED AND THIOETHER-CROSSLINKED PEPTIDOMIMETIC MACROCYCLES | Aileron Therapeutics, Inc. (US) | 2015-01-07 | — | — | EP | disclosed |
| WO-2014138429-A2 | PEPTIDOMIMETIC MACROCYCLES AND USE THEREOF IN REGULATING HIF1ALPHA | AILERON THERAPEUTICS, INC. (US) | 2014-09-12 | — | — | WO | disclosed |
| EP-2768518-A1 | PEPTIDOMIMETIC MACROCYLES | Aileron Therapeutics, Inc. (US) | 2014-08-27 | — | — | EP | disclosed |
| WO-2013123267-A1 | TRIAZOLE-CROSSLINKED AND THIOETHER-CROSSLINKED PEPTIDOMIMETIC MACROCYCLES | AILERON THERAPEUTICS, INC. (US) | 2013-08-22 | — | — | WO | disclosed |
| WO-2013123266-A1 | PEPTIDOMIMETIC MACROCYCLES | AILERON THERAPEUTICS, INC. (US) | 2013-08-22 | — | — | WO | disclosed |
| WO-2013059525-A1 | PEPTIDOMIMETIC MACROCYLES | AILERON THERAPEUTICS, INC. (US) | 2013-04-25 | — | — | WO | disclosed |
| WO-2012173846-A2 | PEPTIDOMIMETIC MACROCYCLES | AILERON THERAPEUTICS, INC. (US) | 2012-12-20 | — | — | WO | disclosed |