Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | ANPEP | P15144 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1419560 | 0.86 | KMT2A (0.53) | MTNR1AMTNR1BHPGDHTTTSHR | |
| SCHEMBL14678382 | 0.85 | HPGD (0.54) | MTNR1AMTNR1BHPGDHTTTSHR | |
| SCHEMBL6695813 | 0.84 | MTNR1A (0.53) | MTNR1AMTNR1BHPGDHTTTSHR | |
| SCHEMBL14251417 | 0.83 | L3MBTL1 (0.51) | TSHRALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL23987637 | 0.83 | MTNR1A (0.56) | MTNR1AMTNR1BHPGDHTTTSHR | |
| SCHEMBL747405 | 0.82 | TSHR (0.51) | MTNR1AMTNR1BHPGDHTTTSHR | |
| SCHEMBL4282666 | 0.81 | MTNR1A (0.50) | MTNR1AMTNR1BHPGDHTTTSHR | |
| SCHEMBL17478028 | 0.81 | MTNR1A (0.50) | MTNR1AMTNR1BHPGDHTTALDH1A1 | |
| SCHEMBL14874304 | 0.81 | HPGD (0.50) | MTNR1AMTNR1BHPGDHTTTSHR | |
| SCHEMBL27942554 | 0.79 | MTNR1A (0.51) | MTNR1AMTNR1BHPGDHTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2721019-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE | Agios Pharmaceuticals, Inc. (US) | 2014-04-23 | — | — | EP | disclosed |
| WO-2012171337-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-12-20 | — | — | WO | disclosed |