Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6695813 | 0.83 | MTNR1A (0.53) | MTNR1AMTNR1BALDH1A1HPGDHTT | |
| SCHEMBL14250613 | 0.81 | MTNR1A (0.51) | MTNR1AMTNR1BALDH1A1HPGDHTT | |
| SCHEMBL17478028 | 0.80 | MTNR1A (0.50) | MTNR1AMTNR1BALDH1A1HPGDHTT | |
| SCHEMBL17670826 | 0.79 | ALDH1A1 (0.49) | MTNR1AMTNR1BALDH1A1HPGDHTT | |
| SCHEMBL9480529 | 0.78 | IDO1 (0.52) | MTNR1AMTNR1BALDH1A1HPGDHTT | |
| SCHEMBL28805376 | 0.78 | IDO1 (0.52) | ALDH1A1MEN1KMT2AIDO1TAAR1 | |
| SCHEMBL27942554 | 0.78 | MTNR1A (0.51) | MTNR1AMTNR1BALDH1A1HPGDHTT | |
| SCHEMBL7385695 | 0.76 | CYP1A2 (0.59) | MTNR1AMTNR1BALDH1A1HPGDHTT | |
| SCHEMBL6206375 | 0.75 | IDO1 (0.48) | MTNR1AMTNR1BALDH1A1HPGDHTT | |
| SCHEMBL2426744 | 0.75 | ALDH1A1 (0.46) | MTNR1AMTNR1BALDH1A1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009150196-A1 | N-THIAZOLYL-1, 2, 3, 4-TETRAHYDRO-6-ISOQUINOLINECARBOXAMIDE DERIVATIVES AS INHIBITORS OF STEAROYL COENZYME A DESATURASE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-17 | — | — | WO | disclosed |
| WO-2009150196-A1 | N-THIAZOLYL-1, 2, 3, 4-TETRAHYDRO-6-ISOQUINOLINECARBOXAMIDE DERIVATIVES AS INHIBITORS OF STEAROYL COENZYME A DESATURASE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-17 | — | — | WO | disclosed |