Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 5/20 | 0.53 |
| ▸ | BCR | P11274 | 5/20 | 0.53 |
| ▸ | SRC | P12931 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | PRKCA | P17252 | 4/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14254214 | 0.82 | ABL1 (0.55) | SYKABL1BCRSRCPRKCA | |
| SCHEMBL14254204 | 0.82 | PIK3CG (0.65) | SYKABL1BCRSRCNPC1 | |
| SCHEMBL4903303 | 0.81 | ABL1 (0.66) | SYKABL1BCRSRCNPC1 | |
| SCHEMBL14253963 | 0.81 | PLK1 (0.57) | ABL1BCRSRCPRKCAJAK2 | |
| SCHEMBL5732836 | 0.81 | SYK (0.61) | SYKABL1BCRSRCNPC1 | |
| SCHEMBL1927060 | 0.80 | ABL1 (0.80) | SYKABL1BCRSRCNPC1 | |
| SCHEMBL14254272 | 0.80 | ABL1 (0.53) | ABL1BCRSRCPRKCAJAK2 | |
| SCHEMBL14254259 | 0.80 | CAMK2D (0.61) | ABL1BCRSRCNPC1RAB9A | |
| SCHEMBL14254261 | 0.80 | PIK3CG (0.62) | SYKABL1BCRSRCPRKCA | |
| SCHEMBL4904236 | 0.80 | ABL1 (0.58) | SYKABL1BCRSRCNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348335-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-03-25 | — | — | US | disclosed |
| US-7348335-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-03-25 | — | — | US | disclosed |