Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 6/20 | 0.65 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.65 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | JAK2 | O60674 | 3/20 | 0.55 |
| ▸ | FLT3 | P36888 | 2/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | BCR | P11274 | 2/20 | 0.51 |
| ▸ | PRKCA | P17252 | 2/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14253938 | 0.89 | PIK3CG (0.66) | PIK3CGPIK3CAPIK3CBMEN1KMT2A | |
| SCHEMBL14254214 | 0.87 | ABL1 (0.55) | PIK3CGPIK3CAPIK3CBJAK2FLT3 | |
| SCHEMBL14253963 | 0.85 | PLK1 (0.57) | PIK3CGPIK3CAPIK3CBMEN1KMT2A | |
| SCHEMBL14254274 | 0.85 | ABCG2 (0.54) | PIK3CGPIK3CAPIK3CBMEN1KMT2A | |
| SCHEMBL14254261 | 0.85 | PIK3CG (0.62) | PIK3CGPIK3CAPIK3CBJAK2FLT3 | |
| SCHEMBL14254272 | 0.85 | ABL1 (0.53) | PIK3CGPIK3CAPIK3CBJAK2FLT3 | |
| SCHEMBL14254259 | 0.85 | CAMK2D (0.61) | PIK3CGPIK3CAPIK3CBJAK2FLT3 | |
| SCHEMBL14254239 | 0.85 | PIK3CG (0.60) | PIK3CGPIK3CAPIK3CBMEN1KMT2A | |
| SCHEMBL14254260 | 0.84 | DKK1 (0.59) | PIK3CGPIK3CAPIK3CBMEN1KMT2A | |
| SCHEMBL14254267 | 0.83 | PIK3CA (0.53) | PIK3CGPIK3CAPIK3CBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348335-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-03-25 | — | — | US | disclosed |