Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 3/20 | 0.62 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.62 |
| ▸ | GSK3B | P49841 | 2/20 | 0.62 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.62 |
| ▸ | ABL1 | P00519 | 6/20 | 0.55 |
| ▸ | PRKCA | P17252 | 6/20 | 0.55 |
| ▸ | BCR | P11274 | 5/20 | 0.55 |
| ▸ | EGFR | P00533 | 2/20 | 0.55 |
| ▸ | SRC | P12931 | 2/20 | 0.55 |
| ▸ | PLK1 | P53350 | 3/20 | 0.54 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.48 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | PRKCG | P05129 | 1/20 | 0.48 |
| ▸ | PRKCB | P05771 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14253963 | 0.92 | PLK1 (0.57) | PIK3CGMAPK8GSK3BCAMKK2ABL1 | |
| SCHEMBL14254214 | 0.89 | ABL1 (0.55) | PIK3CGMAPK8GSK3BCAMKK2ABL1 | |
| SCHEMBL14254259 | 0.88 | CAMK2D (0.61) | PIK3CGABL1PRKCABCREGFR | |
| SCHEMBL14254272 | 0.88 | ABL1 (0.53) | PIK3CGMAPK8GSK3BCAMKK2ABL1 | |
| SCHEMBL14254260 | 0.86 | DKK1 (0.59) | PIK3CGGSK3BABL1PRKCABCR | |
| SCHEMBL14253939 | 0.85 | PIK3CG (0.56) | PIK3CGMAPK8GSK3BCAMKK2ABL1 | |
| SCHEMBL14254204 | 0.85 | PIK3CG (0.65) | PIK3CGMAPK8GSK3BABL1PRKCA | |
| SCHEMBL14254276 | 0.82 | PIK3CA (0.51) | PIK3CGGSK3BABL1PRKCABCR | |
| SCHEMBL14254270 | 0.82 | SRC (0.50) | PIK3CGABL1PRKCABCREGFR | |
| SCHEMBL14254254 | 0.82 | PIK3CA (0.68) | PIK3CGGSK3BABL1PRKCABCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348335-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-03-25 | — | — | US | disclosed |