Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20494596 | 0.86 | MAPT (0.43) | MAPTSIGMAR1HDAC11GBA1 | |
| SCHEMBL21049584 | 0.83 | CCR3 (0.44) | CCR3SIGMAR1 | |
| SCHEMBL23326764 | 0.82 | MAPT (0.43) | MAPTSIGMAR1HDAC11GBA1 | |
| SCHEMBL9697554 | 0.81 | SIGMAR1 (0.43) | MAPTSIGMAR1HDAC11GBA1 | |
| SCHEMBL9696934 | 0.81 | SIGMAR1 (0.43) | MAPTSIGMAR1HDAC11GBA1 | |
| SCHEMBL20734689 | 0.81 | SIGMAR1 (0.55) | MAPTSIGMAR1GBA1 | |
| SCHEMBL5371008 | 0.81 | MAPT (0.50) | MAPTSIGMAR1HDAC11GBA1 | |
| SCHEMBL15325592 | 0.81 | MAPT (0.50) | MAPTSIGMAR1HDAC11GBA1 | |
| SCHEMBL6942852 | 0.81 | MAPT (0.50) | MAPTSIGMAR1HDAC11GBA1 | |
| SCHEMBL10130060 | 0.81 | MAPT (0.50) | MAPTSIGMAR1HDAC11GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7338965-B2 | 3,4-disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines | PHARMACIA & UPJOHN COMPANY (US) | 2008-03-04 | — | — | US | disclosed |
| US-7338965-B2 | 3,4-disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines | PHARMACIA & UPJOHN COMPANY (US) | 2008-03-04 | — | — | US | disclosed |