Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 5/20 | 0.52 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.49 |
| ▸ | PDE5A | O76074 | 2/20 | 0.49 |
| ▸ | ACP1 | P24666 | 2/20 | 0.49 |
| ▸ | OGG1 | O15527 | 1/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GBA1 | P04062 | 4/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.44 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14256444 | 0.99 | MERTK (0.53) | MERTKNPY5RCXCR4PDE5AACP1 | |
| SCHEMBL14256700 | 0.90 | APP (0.46) | MERTKNPY5RCXCR4ACP1APP | |
| SCHEMBL14412272 | 0.90 | CXCR4 (0.52) | MERTKCXCR4APPBCHEACHE | |
| SCHEMBL14256451 | 0.90 | MERTK (0.52) | MERTKNPY5RCXCR4PDE5AACP1 | |
| SCHEMBL14256546 | 0.89 | MERTK (0.51) | MERTKNPY5RCXCR4PDE5AACP1 | |
| SCHEMBL14256454 | 0.88 | MERTK (0.46) | MERTKNPY5RCXCR4PDE5AACP1 | |
| SCHEMBL14412234 | 0.88 | GBA1 (0.49) | MERTKAPPBCHEACHEKMT2A | |
| SCHEMBL14256450 | 0.87 | MERTK (0.52) | MERTKNPY5RCXCR4PDE5AACP1 | |
| SCHEMBL14412248 | 0.86 | APP (0.45) | MERTKNPY5RCXCR4ACP1TLR7 | |
| SCHEMBL14256696 | 0.85 | LATS1 (0.41) | MERTKNPY5RCXCR4APPBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080058312-A1 | Modulators of hepatocyte growth factor/c-Met activity | ANGION BIOMEDICA CORPORATION (US) | 2008-03-06 | — | — | US | disclosed |
| US-20080058312-A1 | Modulators of hepatocyte growth factor/c-Met activity | ANGION BIOMEDICA CORPORATION (US) | 2008-03-06 | — | — | US | disclosed |
| US-20070213319-A1 | Modulators of hepatocyte growth factor/c-Met activity | ANGION BIOMEDICA CORPORATION (US) | 2007-09-13 | — | — | US | disclosed |
| US-20070213319-A1 | Modulators of hepatocyte growth factor/c-Met activity | ANGION BIOMEDICA CORPORATION (US) | 2007-09-13 | — | — | US | disclosed |
| WO-2007081978-A2 | MODULATORS OF HEPATOCYTE GROWTH FACTOR / C-MET ACTIVITY | ANGION BIOMEDICA CORPORATION (US) | 2007-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213319-A1 | Modulators of hepatocyte growth factor/c-Met activity | HGF, MET, HDGF | MERTK 73/4885NPY5R 3164/4885CXCR4 909/4885 |
| US-20080058312-A1 | Modulators of hepatocyte growth factor/c-Met activity | HGF, MET, HDGF | MERTK 58/4885NPY5R 3095/4885CXCR4 958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.