Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 3/20 | 0.44 |
| ▸ | CA9 | Q16790 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21241487 | 0.77 | POLB (0.47) | MAPTALDH1A1CA12CA9CA2 | |
| SCHEMBL3467608 | 0.71 | MAPT (0.63) | MAPTMCOLN3ALDH1A1TSHRCA12 | |
| SCHEMBL8278827 | 0.70 | ALDH1A1 (0.55) | MAPTMCOLN3ALDH1A1TSHRMAPK1 | |
| SCHEMBL12994623 | 0.69 | MAPT (0.48) | MAPTMCOLN3ALDH1A1TSHRCA12 | |
| SCHEMBL24604208 | 0.69 | ALDH1A1 (0.52) | MAPTMCOLN3ALDH1A1TSHRLMNA | |
| SCHEMBL12789301 | 0.69 | ALDH1A1 (0.52) | MAPTMCOLN3ALDH1A1TSHRCA12 | |
| SCHEMBL12569403 | 0.69 | ALDH1A1 (0.52) | MAPTMCOLN3ALDH1A1TSHRTDP1 | |
| SCHEMBL26081358 | 0.69 | ALDH1A1 (0.52) | MAPTMCOLN3ALDH1A1TSHRTDP1 | |
| SCHEMBL12298626 | 0.68 | RAB9A (0.42) | MAPTMCOLN3ALDH1A1TSHRCA12 | |
| SCHEMBL10192055 | 0.68 | MAPT (0.59) | MAPTMCOLN3ALDH1A1TSHRCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008025509-A1 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL IN THE TREATMENT OF CANCERS OF THE CENTRAL NERVOUS SYSTEM | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-03-06 | — | — | WO | disclosed |