SCHEMBL14259481

SCHEMBL14259481

COc1cccc(Cc2ccc(C)cc2)n1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MPO P05164 1/20 0.43
MAOB P27338 2/20 0.40
KDM1A O60341 1/20 0.40
MAOA P21397 1/20 0.40
MAPK1 P28482 2/20 0.38
MAPT P10636 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
PDE10A Q9Y233 1/20 0.38
TXNRD1 Q16881 1/20 0.38
KEAP1 Q14145 1/20 0.38
NFE2L2 Q16236 1/20 0.38
ALOX5 P09917 1/20 0.38
BTK Q06187 1/20 0.36
BRD4 O60885 1/20 0.36
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
TDP1 Q9NUW8 2/20 0.36
TSHR P16473 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
LTA4H P09960 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5229072 0.86 BRD4 (0.49) MPOMAOBKDM1AMAOAPDE10A
SCHEMBL13155262 0.82 MPO (0.40) MPOMAOBKDM1AMAOAL3MBTL1
SCHEMBL28031732 0.81 MPO (0.49) MPOMAOBKDM1AMAOAALOX5
Bromide SCHEMBL9391624 0.77 MBOAT4 (0.42) MAOBKDM1AMAOAMAPK1MAPT
SCHEMBL18586953 0.77 MPO (0.56) MPOMAOBKDM1AMAOAMAPT
SCHEMBL21982559 0.76 MPO (0.44) MPOMAOBKDM1AMAOAPDE4D
SCHEMBL10366468 0.75 KEAP1 (0.39) MAOBMAOAMAPK1MAPTL3MBTL1
SCHEMBL21939013 0.75 MPO (0.42) MPOMAOBKDM1AMAOAPDE10A
SCHEMBL18586840 0.74 MPO (0.40) MPOMAOBKDM1AMAOAPDE10A
SCHEMBL217520 0.74 KDM1A (0.45) MPOMAOBKDM1AMAOAPDE10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008025509-A1 BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL IN THE TREATMENT OF CANCERS OF THE CENTRAL NERVOUS SYSTEM BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-03-06 WO disclosed