Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 9/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.33 |
| ▸ | MPO | P05164 | 2/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL764162 | 0.82 | LMNA (0.33) | LMNA | |
| SCHEMBL764855 | 0.82 | LMNA (0.39) | LMNAADRB2ADRB1MPOSCN8A | |
| SCHEMBL13392154 | 0.82 | LMNA (0.39) | LMNAADRB2ADRB1CYP3A4KMT2A | |
| SCHEMBL14046946 | 0.81 | MPO (0.33) | MPOSCN8ASLC6A4TAAR1 | |
| SCHEMBL14260258 | 0.81 | KDM4E (0.38) | LMNAADRB2ADRB1KMT2AKDM4E | |
| SCHEMBL14260234 | 0.81 | LMNA (0.34) | LMNAADRB2ADRB1KMT2AKDM4E | |
| SCHEMBL14046821 | 0.80 | ADRB2 (0.52) | ADRB2ADRB1 | |
| SCHEMBL14260230 | 0.77 | LMNA (0.35) | LMNAADRB2ADRB1KMT2AMEN1 | |
| SCHEMBL28634561 | 0.75 | LMNA (0.52) | LMNAADRB2ADRB1SCN8ASLC6A4 | |
| SCHEMBL13392163 | 0.71 | LMNA (0.39) | LMNAADRB2ADRB1SCN8ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033328-A2 | MACROCYCLIC ANTAGONISTS OF THE MOTILIN RECEPTOR FOR TREATMENT OF GASTROINTESTINAL DYSMOTILITY DISORDERS | TRANZYME PHARMA, INC. (US) | 2008-03-20 | — | — | WO | disclosed |