Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 9/20 | 0.44 |
| ▸ | PPARA | Q07869 | 9/20 | 0.44 |
| ▸ | PPARD | Q03181 | 2/20 | 0.43 |
| ▸ | ICMT | O60725 | 1/20 | 0.39 |
| ▸ | PTPRB | P23467 | 1/20 | 0.38 |
| ▸ | SHMT1 | P34896 | 3/20 | 0.37 |
| ▸ | SHMT2 | P34897 | 3/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730467 | 1.00 | PPARG (0.44) | PPARGPPARAPPARDICMTPTPRB | |
| SCHEMBL4728145 | 0.95 | PPARG (0.47) | PPARGPPARAPPARDICMTPTPRB | |
| SCHEMBL14260755 | 0.95 | PPARG (0.47) | PPARGPPARAPPARDICMTPTPRB | |
| SCHEMBL4731059 | 0.93 | PPARG (0.36) | PPARGPPARAPPARDPTPRBSHMT1 | |
| SCHEMBL14260756 | 0.90 | CCR2 (0.36) | PPARGPPARAICMTPTPRBSHMT1 | |
| SCHEMBL3866899 | 0.84 | PPARA (0.56) | PPARGPPARAPPARDICMTGGPS1 | |
| SCHEMBL13897522 | 0.84 | PPARA (0.58) | PPARGPPARAPPARDICMTGGPS1 | |
| SCHEMBL3866049 | 0.84 | PPARA (0.58) | PPARGPPARAPPARDICMTGGPS1 | |
| SCHEMBL4730121 | 0.83 | P2RY12 (0.37) | PPARGPPARAICMTFNTAFNTB | |
| SCHEMBL3867029 | 0.81 | PPARG (0.46) | PPARGPPARAPPARDICMTGGPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033934-A1 | SUBSTITUTED HETEROARYL CARBOXYLIC ACID DERIVATIVES AS PTB-1B INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-03-20 | — | — | WO | disclosed |