Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.36 |
| ▸ | PPARA | Q07869 | 3/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.36 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.36 |
| ▸ | PTPRB | P23467 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.35 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730467 | 0.93 | PPARG (0.44) | PPARGPPARACCR2PTPRBPPARD | |
| SCHEMBL14260809 | 0.93 | PPARG (0.44) | PPARGPPARACCR2PTPRBPPARD | |
| SCHEMBL14260756 | 0.89 | CCR2 (0.36) | PPARGPPARACCR2PTPRBGGPS1 | |
| SCHEMBL4728145 | 0.88 | PPARG (0.47) | PPARGPPARAPTPRBPPARDGAA | |
| SCHEMBL14260755 | 0.88 | PPARG (0.47) | PPARGPPARAPTPRBPPARDGAA | |
| SCHEMBL3866879 | 0.81 | PPARA (0.50) | PPARGPPARAGSTP1GSTM2NFKB1 | |
| SCHEMBL3866499 | 0.81 | PPARA (0.50) | PPARGPPARAGSTP1GSTM2NFKB1 | |
| SCHEMBL13897379 | 0.81 | GSTP1 (0.42) | PPARGPPARAGSTP1GSTM2NFKB1 | |
| SCHEMBL3871194 | 0.81 | GSTP1 (0.42) | PPARGPPARAGSTP1GSTM2NFKB1 | |
| SCHEMBL4730121 | 0.78 | P2RY12 (0.37) | PPARGPPARAMAPTGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033934-A1 | SUBSTITUTED HETEROARYL CARBOXYLIC ACID DERIVATIVES AS PTB-1B INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-03-20 | — | — | WO | disclosed |