Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 9/20 | 0.47 |
| ▸ | PPARA | Q07869 | 9/20 | 0.47 |
| ▸ | PPARD | Q03181 | 2/20 | 0.45 |
| ▸ | PTPRB | P23467 | 2/20 | 0.40 |
| ▸ | ICMT | O60725 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14260755 | 1.00 | PPARG (0.47) | PPARGPPARAPPARDPTPRBICMT | |
| SCHEMBL4730467 | 0.95 | PPARG (0.44) | PPARGPPARAPPARDPTPRBICMT | |
| SCHEMBL14260809 | 0.95 | PPARG (0.44) | PPARGPPARAPPARDPTPRBICMT | |
| SCHEMBL4730121 | 0.88 | P2RY12 (0.37) | PPARGPPARAICMTPTPN1PRNP | |
| SCHEMBL4731059 | 0.88 | PPARG (0.36) | PPARGPPARAPPARDPTPRBGAA | |
| SCHEMBL4817129 | 0.86 | PPARA (0.61) | PPARGPPARAPPARDICMTPTPN1 | |
| SCHEMBL3863447 | 0.86 | PPARA (0.61) | PPARGPPARAPPARDICMTPTPN1 | |
| SCHEMBL13897433 | 0.85 | PPARA (0.51) | PPARGPPARAPPARDICMTPTPN1 | |
| SCHEMBL14260756 | 0.84 | CCR2 (0.36) | PPARGPPARAPTPRBICMTPTPN1 | |
| SCHEMBL13897395 | 0.84 | PPARA (0.55) | PPARGPPARAPPARDICMTPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033934-A1 | SUBSTITUTED HETEROARYL CARBOXYLIC ACID DERIVATIVES AS PTB-1B INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008033934-A1 | SUBSTITUTED HETEROARYL CARBOXYLIC ACID DERIVATIVES AS PTB-1B INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-03-20 | — | — | WO | disclosed |