Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 12/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4979388 | 0.89 | P2RX7 (0.54) | P2RX7ALDH1A1SSTR4DRD4SSTR1 | |
| SCHEMBL4982989 | 0.89 | NPC1 (0.57) | P2RX7ALDH1A1SSTR4DRD4SSTR1 | |
| SCHEMBL4981471 | 0.86 | ALDH1A1 (0.64) | P2RX7ALDH1A1SSTR4DRD4SSTR1 | |
| SCHEMBL4982505 | 0.83 | DRD4 (0.51) | P2RX7ALDH1A1SSTR4DRD4SSTR1 | |
| SCHEMBL4979013 | 0.80 | ALDH1A1 (0.73) | P2RX7ALDH1A1SSTR4DRD4SSTR1 | |
| SCHEMBL4981938 | 0.80 | POLB (0.51) | ALDH1A1SSTR4TSHRSMN1; SMN2DRD4 | |
| SCHEMBL4979531 | 0.80 | TYRO3 (0.54) | P2RX7ALDH1A1SSTR4DRD4 | |
| SCHEMBL4982809 | 0.79 | DRD4 (0.49) | P2RX7ALDH1A1SSTR4SMN1; SMN2DRD4 | |
| SCHEMBL4981612 | 0.77 | DRD4 (0.57) | P2RX7SMN1; SMN2DRD4MAPT | |
| SCHEMBL4980687 | 0.77 | HPGD (0.52) | ALDH1A1SSTR4TSHRSMN1; SMN2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080064706-A1 | Piperidine Derivatives as Histamine H3 Receptor Ligands | ASTRAZENECA AB (SE) | 2008-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064706-A1 | Piperidine Derivatives as Histamine H3 Receptor Ligands | HRH3, HRH1, HRH4 | P2RX7 310/4885ALDH1A1 451/4885SSTR4 654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.