Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 2/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.73 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.44 |
| ▸ | RELA | Q04206 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14370170 | 1.00 | HTR1B (0.73) | HTR1BKCNH2NPC1RAB9AL3MBTL1 | |
| SCHEMBL5354642 | 1.00 | HTR1B (0.73) | HTR1BKCNH2NPC1RAB9AL3MBTL1 | |
| SCHEMBL22411172 | 0.87 | HTR1B (0.57) | HTR1BKCNH2L3MBTL1ALDH1A1MAPT | |
| SCHEMBL5308358 | 0.87 | HTR1B (0.79) | HTR1BKCNH2NPC1RAB9AALDH1A1 | |
| SCHEMBL5308451 | 0.86 | HTR1B (0.78) | HTR1BKCNH2NPC1RAB9AL3MBTL1 | |
| SCHEMBL4247675 | 0.84 | HTR1B (1.00) | HTR1BKCNH2NPC1RAB9AALDH1A1 | |
| SCHEMBL4247047 | 0.84 | HTR1B (1.00) | HTR1BKCNH2NPC1RAB9AALDH1A1 | |
| SCHEMBL14264000 | 0.84 | HTR1B (0.57) | HTR1BKCNH2NPC1RAB9AL3MBTL1 | |
| SCHEMBL14370221 | 0.84 | HTR1B (0.57) | HTR1BKCNH2NPC1RAB9AL3MBTL1 | |
| SCHEMBL22410996 | 0.84 | HTR1B (0.53) | HTR1BKCNH2NPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076759-A1 | Therapeutic Heterocyclic Compounds 507 | ASTRAZENECA AB (SE) | 2008-03-27 | — | — | US | disclosed |
| US-20080076759-A1 | Therapeutic Heterocyclic Compounds 507 | ASTRAZENECA AB (SE) | 2008-03-27 | — | — | US | disclosed |
| US-7285662-B2 | Therapeutic heterocyclic compounds | ASTRAZENECA AB (SE) | 2007-10-23 | — | — | US | disclosed |
| US-7285662-B2 | Therapeutic heterocyclic compounds | ASTRAZENECA AB (SE) | 2007-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076759-A1 | Therapeutic Heterocyclic Compounds 507 | HTR1A, HTR1B, HTR1D | HTR1B 2/4885KCNH2 2598/4885NPC1 2459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.