Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 3/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14264000 | 1.00 | HTR1B (0.57) | HTR1BKCNH2RAD52L3MBTL1MAPT | |
| SCHEMBL14370170 | 0.84 | HTR1B (0.73) | HTR1BKCNH2RAD52L3MBTL1MAPT | |
| SCHEMBL5354642 | 0.84 | HTR1B (0.73) | HTR1BKCNH2RAD52L3MBTL1MAPT | |
| SCHEMBL14263999 | 0.84 | HTR1B (0.73) | HTR1BKCNH2RAD52L3MBTL1MAPT | |
| SCHEMBL14370172 | 0.83 | HTR1B (0.62) | HTR1BKCNH2RAD52MAPTTSHR | |
| SCHEMBL5311146 | 0.81 | HTR1B (0.56) | HTR1BKCNH2RAD52L3MBTL1MAPT | |
| SCHEMBL4988581 | 0.78 | LMNA (0.45) | L3MBTL1MAPTALDH1A1TSHRMEN1 | |
| Hydrochloric Acid SCHEMBL6608472 | 0.77 | LMNA (0.44) | L3MBTL1MAPTALDH1A1TSHRMEN1 | |
| SCHEMBL4806699 | 0.75 | ALDH1A1 (0.54) | HTR1BKCNH2RAD52L3MBTL1MAPT | |
| SCHEMBL5308358 | 0.75 | HTR1B (0.79) | HTR1BKCNH2RAD52MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7285662-B2 | Therapeutic heterocyclic compounds | ASTRAZENECA AB (SE) | 2007-10-23 | — | — | US | disclosed |
| US-7285662-B2 | Therapeutic heterocyclic compounds | ASTRAZENECA AB (SE) | 2007-10-23 | — | — | US | disclosed |