Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 6/20 | 0.33 |
| ▸ | CTSB | P07858 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12378079 | 0.91 | DHPS (0.39) | COMTKDM4ESMN1; SMN2L3MBTL1RAB9A | |
| SCHEMBL12378216 | 0.90 | COMT (0.35) | COMTCTSBKDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL4752157 | 0.90 | CTSB (0.40) | COMTCTSBKDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL5650719 | 0.89 | MAPT (0.38) | COMTKDM4ESMN1; SMN2L3MBTL1RAB9A | |
| SCHEMBL29390607 | 0.89 | KDM4E (0.39) | COMTKDM4ESMN1; SMN2L3MBTL1RAB9A | |
| SCHEMBL4652222 | 0.89 | KDM4E (0.39) | COMTKDM4ESMN1; SMN2L3MBTL1RAB9A | |
| SCHEMBL4689848 | 0.89 | COMT (0.38) | COMTKDM4ESMN1; SMN2L3MBTL1RAB9A | |
| SCHEMBL14573665 | 0.87 | ALDH1A1 (0.41) | KDM4ESMN1; SMN2L3MBTL1MAPTTDP1 | |
| SCHEMBL4750446 | 0.86 | TP53 (0.39) | COMTKDM4ESMN1; SMN2L3MBTL1RAB9A | |
| SCHEMBL4693347 | 0.86 | COMT (0.38) | COMTKDM4ESMN1; SMN2L3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080058315-A1 | Integrase inhibitors | GILEAD SCIENCES, INC. | 2008-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058315-A1 | Integrase inhibitors | TYMP, DNTT, PAICS | COMT 719/4885CTSB 1373/4885KDM4E 1971/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.