Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 12/20 | 0.49 |
| ▸ | CNR1 | P21554 | 6/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 5/20 | 0.42 |
| ▸ | ACHE | P22303 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6638106 | 0.80 | LTB4R2 (0.47) | CNR2CNR1HDAC6AGTR1AGTR2 | |
| SCHEMBL6638110 | 0.78 | CNR2 (0.42) | CNR2CNR1HDAC6AGTR1AGTR2 | |
| SCHEMBL6304715 | 0.69 | SMO (0.40) | CNR2CNR1HDAC6AGTR1AGTR2 | |
| SCHEMBL6323123 | 0.69 | AGTR1 (0.44) | AGTR1AGTR2TP53 | |
| SCHEMBL6298905 | 0.68 | CNR2 (0.48) | CNR2CNR1HDAC6BCHEACHE | |
| SCHEMBL5109494 | 0.67 | TBXA2R (0.38) | CNR2CNR1AGTR1AGTR2BCHE | |
| SCHEMBL14266733 | 0.67 | TP53 (0.41) | CNR2CNR1TP53 | |
| SCHEMBL6298910 | 0.67 | CNR2 (0.50) | CNR2CNR1BCHEACHE | |
| SCHEMBL14266729 | 0.67 | AGTR1 (0.48) | AGTR1AGTR2BCHEACHETP53 | |
| SCHEMBL1283291 | 0.66 | CNR2 (0.47) | CNR2CNR1BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348326-B2 | Heteroaryl fused aminoalkyl imidazole derivatives: selective modulators of GABAa receptors | NEUROGEN CORPORATION (US) | 2008-03-25 | — | — | US | disclosed |
| US-7348326-B2 | Heteroaryl fused aminoalkyl imidazole derivatives: selective modulators of GABAa receptors | NEUROGEN CORPORATION (US) | 2008-03-25 | — | — | US | disclosed |