Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL671 | 0.86 | PPARG (0.67) | PPARG | |
| SCHEMBL7359247 | 0.85 | AGTR2 (0.67) | PPARG | |
| SCHEMBL306 | 0.81 | AGTR1 (0.76) | — | |
| SCHEMBL33 | 0.81 | AGTR1 (0.75) | — | |
| SCHEMBL9756284 | 0.80 | AGTR1 (0.67) | PPARG | |
| SCHEMBL684085 | 0.80 | AGTR1 (0.71) | PPARG | |
| SCHEMBL181 | 0.78 | AGTR1 (0.73) | — | |
| SCHEMBL29833187 | 0.77 | PPARG (0.70) | PPARG | |
| SCHEMBL29833188 | 0.77 | PPARG (0.70) | PPARG | |
| SCHEMBL8396958 | 0.77 | PPARG (1.00) | PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019048-B1 | USE OF AN ANGIOTENSIN II RECEPTOR ANTAGONIST FOR THE PREPARATION OF DRUGS TO INCREASE THE SURVIVAL RATE OF RENAL TRANSPLANT PATIENTS | MERCK SHARP DOHME ITALIA S P A (IT) | 2004-01-21 | — | — | EP | claimed |
| US-5155118-A | Administering angiotensin inhibitor | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-10-13 | — | — | US | claimed |
| US-5153197-A | Treatment of hypertension with angiotensin II blocking imidazoles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-10-06 | — | — | US | claimed |
| US-5138069-A | Treating hypertension and congestive heart failure | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-08-11 | — | — | US | claimed |
| US-5128355-A | Hypotensive | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-07-07 | — | — | US | claimed |
| US-5663187-A | ANTICHOLESTEROL AGENTS AND ENZYME INHIBITORS | MERCK & CO., INC. (US) | 1997-09-02 | — | — | US | disclosed |