SCHEMBL7359247

SCHEMBL7359247

CCCc1nc(-c2ccccc2)c(C=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1

nearest known ligand 0.71

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR2 P50052 1/20 0.67
PPARG P37231 4/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL671 0.89 PPARG (0.67) PPARG
SCHEMBL1427 0.85 PPARG (0.66) PPARG
SCHEMBL33 0.83 AGTR1 (0.75) AGTR2
SCHEMBL9756284 0.82 AGTR1 (0.67) AGTR2PPARG
SCHEMBL7362569 0.80 AGTR2 (0.72) AGTR2
SCHEMBL29833187 0.79 PPARG (0.70) PPARG
SCHEMBL29833188 0.79 PPARG (0.70) PPARG
SCHEMBL8396958 0.79 PPARG (1.00) AGTR2PPARG
SCHEMBL9127263 0.78 AGTR1 (0.67) AGTR2
SCHEMBL9531803 0.78 PPARG (0.55) AGTR2PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0803252-A2 Treatment of central nervous system disorders with imidazole angiotensin-II receptor antagonists E.I. DU PONT DE NEMOURS AND COMPANY (US) 1997-10-29 EP claimed
EP-0533840-B1 TREATMENT OF CHRONIC RENAL FAILURE WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS DU PONT (US) 1996-12-11 EP claimed
US-5210079-A Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists E. I. DU PONT DE NEMOURS AND COMPANY (US) 1993-05-11 US claimed
EP-0524946-A4 TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS 1993-03-24 EP claimed
EP-0524946-A1 TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-02-03 EP claimed
US-5140037-A Administering cognition activators E. I. DU PONT DE NEMOURS AND COMPANY (US) 1992-08-18 US claimed
US-5138069-A Treating hypertension and congestive heart failure E. I. DU PONT DE NEMOURS AND COMPANY (US) 1992-08-11 US claimed
WO-1992000067-A2 TREATMENT OF CHRONIC RENAL FAILURE WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-01-09 WO claimed
WO-1991015206-A1 TREATMENT OF GLAUCOMA AND OCULAR HYPERTENSION WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-10-17 WO claimed
WO-1991014367-A1 TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-10-03 WO claimed
EP-0803252-A2 Treatment of central nervous system disorders with imidazole angiotensin-II receptor antagonists E.I. DU PONT DE NEMOURS AND COMPANY (US) 1997-10-29 EP disclosed
EP-0533840-B1 TREATMENT OF CHRONIC RENAL FAILURE WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS DU PONT (US) 1996-12-11 EP disclosed
US-5210079-A Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists E. I. DU PONT DE NEMOURS AND COMPANY (US) 1993-05-11 US disclosed
EP-0524946-A4 TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS 1993-03-24 EP disclosed
EP-0524946-A1 TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-02-03 EP disclosed
US-5140037-A Administering cognition activators E. I. DU PONT DE NEMOURS AND COMPANY (US) 1992-08-18 US disclosed
WO-1992000067-A2 TREATMENT OF CHRONIC RENAL FAILURE WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-01-09 WO disclosed
WO-1991015206-A1 TREATMENT OF GLAUCOMA AND OCULAR HYPERTENSION WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-10-17 WO disclosed
WO-1991014367-A1 TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-10-03 WO disclosed