Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 3/20 | 0.34 |
| ▸ | GCGR | P47871 | 2/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.30 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1349203 | 0.86 | ADRB3 (0.34) | GCGRADRB3ADRB1ADRB2 | |
| SCHEMBL1348878 | 0.84 | NR3C1 (0.32) | NR3C1NR3C2 | |
| SCHEMBL1348774 | 0.83 | PNP (0.32) | — | |
| SCHEMBL1350811 | 0.79 | GPR84 (0.35) | — | |
| SCHEMBL1349758 | 0.78 | PNP (0.36) | GCGRADRB3CYP3A4NOS1CYP2C19 | |
| SCHEMBL1427183 | 0.77 | HDAC3 (0.36) | NR3C1 | |
| SCHEMBL1349740 | 0.77 | MEN1 (0.32) | NR3C1NR3C2 | |
| SCHEMBL1426920 | 0.77 | MGAM (0.37) | NR3C1GCGR | |
| SCHEMBL1349776 | 0.76 | GPR84 (0.34) | — | |
| SCHEMBL1349194 | 0.76 | OPRM1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300423-A1 | SUBSTITUTED 7-SULFANYLMETHYL, 7-SULFINYLMETHYL AND 7-SULFONYLMETHYL INDOLES AND USE THEREOF | Bayer Schering Pharma Aktiengesellschaft (DE) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009156072-A1 | SUBSTITUTED 7-SULFANYLMETHYL, 7-SULFINYLMETHYL AND 7-SULFONYLMETHYL INDOLES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-12-30 | — | — | WO | disclosed |