Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RB1 | P06400 | 4/20 | 0.83 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.52 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.52 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | CCKAR | P32238 | 1/20 | 0.51 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.48 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | PARG | Q86W56 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834758 | 1.00 | RB1 (0.83) | RB1TBXA2RPTGDR2PTGDRABCB11 | |
| SCHEMBL9833845 | 0.91 | RB1 (0.68) | RB1TBXA2RPTGDR2PTGDRNR2E1 | |
| SCHEMBL9834014 | 0.83 | RB1 (0.59) | RB1TBXA2RHTR6 | |
| SCHEMBL9593099 | 0.82 | RB1 (0.58) | RB1 | |
| Hydrochloric Acid SCHEMBL9592041 | 0.77 | RB1 (0.52) | RB1TBXA2RPTGDR2PTGDRHTR6 | |
| SCHEMBL4803895 | 0.76 | NR2E1 (0.61) | RB1CYP2C9NR2E1 | |
| SCHEMBL9362217 | 0.73 | RB1 (0.50) | RB1TBXA2RPTGDR2PTGDR | |
| SCHEMBL11217331 | 0.73 | SSTR3 (0.64) | RB1DRD1NR2E1SSTR3KCNH2 | |
| SCHEMBL7654341 | 0.72 | MAPT (0.48) | RB1PTGDR2HTR6 | |
| SCHEMBL9834116 | 0.72 | RB1 (0.55) | RB1TBXA2RPTGDR2PTGDRABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501959-B2 | Cycloalkane[B]indole antagonists of prostaglandin D2 receptors | PANMIRA PHARMACEUTICALS, LLC (US) | 2013-08-06 | — | — | US | disclosed |
| US-20110152338-A1 | CYCLOALKANE[B]INDOLE ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-06-23 | — | — | US | disclosed |
| EP-2300425-A2 | CYCLOALKANEÝB¨INDOLE ANGTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2011-03-30 | — | — | EP | disclosed |
| WO-2010008864-A2 | CYCLOALKANE[B]INDOLE ANGTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152338-A1 | CYCLOALKANE[B]INDOLE ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | PTGDR, PTGDR2, PTGER2 | RB1 2858/4885TBXA2R 10/4885PTGDR2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.