Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 0.45 |
| ▸ | RAF1 | P04049 | 15/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14276263 | 0.89 | P2RX3 (0.39) | P2RX3 | |
| SCHEMBL5111493 | 0.87 | BRAF (0.51) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL14276260 | 0.86 | BRAF (0.35) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL4049497 | 0.84 | PPARG (0.41) | — | |
| SCHEMBL14276284 | 0.81 | SMN1; SMN2 (0.34) | — | |
| SCHEMBL14276272 | 0.79 | MEN1 (0.38) | — | |
| SCHEMBL14276270 | 0.79 | KDR (0.39) | BRAFKDR | |
| SCHEMBL14276271 | 0.77 | MAPK14 (0.39) | — | |
| SCHEMBL14276265 | 0.77 | PIK3CA (0.40) | — | |
| SCHEMBL12020936 | 0.75 | KDR (0.55) | BRAFRAF1KDRLCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335657-B2 | Cytokine inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| US-7335657-B2 | Cytokine inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |