Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 5/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14276270 | 0.87 | KDR (0.39) | MAPK14NOD2NOD1SMN1; SMN2MAPT | |
| SCHEMBL4049497 | 0.84 | PPARG (0.41) | NOD2NOD1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL14276263 | 0.80 | P2RX3 (0.39) | SMN1; SMN2MAPTNPC1RAB9AKDM4E | |
| SCHEMBL14376280 | 0.78 | PPARG (0.48) | NOD2NOD1CYP1A2 | |
| SCHEMBL7884857 | 0.78 | KMT2A (0.47) | NOD2NOD1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL14276261 | 0.77 | BRAF (0.45) | — | |
| SCHEMBL3052830 | 0.77 | NOD2 (0.46) | NOD2NOD1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL14276284 | 0.77 | SMN1; SMN2 (0.34) | NOD2NOD1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL30220535 | 0.77 | JMJD6 (0.41) | NOD2NOD1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL13690239 | 0.77 | TP53 (0.41) | NOD2NOD1SMN1; SMN2MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335657-B2 | Cytokine inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| US-7335657-B2 | Cytokine inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |