Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 6/20 | 0.39 |
| ▸ | PYGL | P06737 | 5/20 | 0.38 |
| ▸ | PYGM | P11217 | 5/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 3/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14276261 | 0.89 | BRAF (0.45) | P2RX3 | |
| SCHEMBL14276260 | 0.89 | BRAF (0.35) | PYGLPYGMCYP1A2MEN1KMT2A | |
| SCHEMBL4049497 | 0.87 | PPARG (0.41) | CYP1A2MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL14276284 | 0.83 | SMN1; SMN2 (0.34) | CYP1A2MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL14276272 | 0.83 | MEN1 (0.38) | PYGLPYGMCYP1A2MEN1KMT2A | |
| SCHEMBL5111493 | 0.80 | BRAF (0.51) | PYGLPYGM | |
| SCHEMBL14276271 | 0.80 | MAPK14 (0.39) | CYP1A2MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5125532 | 0.79 | PPARG (0.48) | PYGLPYGMPPARGKDM4E | |
| SCHEMBL14276265 | 0.79 | PIK3CA (0.40) | KDM4E | |
| SCHEMBL5119451 | 0.79 | RAF1 (0.35) | P2RX3PYGLPYGMPPARGKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335657-B2 | Cytokine inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| US-7335657-B2 | Cytokine inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |