Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 9/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14301982 | 0.75 | NR1H2 (0.49) | RIPK1NR1H2NR1H3 | |
| SCHEMBL13987859 | 0.74 | RIPK1 (0.35) | RIPK1KMT2A | |
| SCHEMBL13987857 | 0.71 | RIPK1 (0.47) | RIPK1ALDH1A1RAB9AKMT2A | |
| SCHEMBL13987854 | 0.68 | DRD2 (0.34) | — | |
| SCHEMBL13661938 | 0.64 | SCN3A (0.34) | ALDH1A1 | |
| SCHEMBL5238027 | 0.64 | AGTR2 (0.32) | — | |
| SCHEMBL26766669 | 0.64 | GRIN2B (0.47) | ALDH1A1 | |
| SCHEMBL14642666 | 0.64 | MEN1 (0.40) | RIPK1ALDH1A1KMT2A | |
| SCHEMBL3740515 | 0.64 | MEN1 (0.40) | RIPK1ALDH1A1KMT2A | |
| SCHEMBL3740511 | 0.64 | MEN1 (0.40) | RIPK1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329762-B2 | Prodrugs of mitotic kinesin inhibitors | MERCK & CO., INC. (US) | 2008-02-12 | — | — | US | disclosed |