Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 11/20 | 0.38 |
| ▸ | DRD4 | P21917 | 10/20 | 0.38 |
| ▸ | DRD2 | P14416 | 9/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3453460 | 0.88 | HRH3 (0.40) | HRH3SIGMAR1HTR1ADRD4DRD2 | |
| SCHEMBL3453155 | 0.87 | DRD4 (0.52) | HRH3SIGMAR1HTR1ADRD4DRD2 | |
| SCHEMBL14277638 | 0.82 | PARP1 (0.47) | HRH3SIGMAR1HTR1APARP1SLC6A4 | |
| SCHEMBL14277663 | 0.81 | PARP1 (0.48) | HRH3SIGMAR1HTR1APARP1SLC6A4 | |
| SCHEMBL3453108 | 0.78 | PPARG (0.48) | HRH3SIGMAR1HTR1APARP1 | |
| SCHEMBL3453738 | 0.77 | PPARG (0.49) | HRH3SIGMAR1HTR1APARP1 | |
| SCHEMBL6589456 | 0.73 | HTR1A (0.52) | HRH3SIGMAR1HTR1ADRD4DRD2 | |
| SCHEMBL14277640 | 0.72 | PARP1 (0.47) | SIGMAR1HTR1APARP1SLC6A3 | |
| SCHEMBL14277641 | 0.71 | PARP1 (0.48) | SIGMAR1HTR1ADRD2PARP1SLC6A4 | |
| SCHEMBL6589037 | 0.71 | SIGMAR1 (0.44) | HRH3SIGMAR1HTR1ADRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7326723-B2 | Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2008-02-05 | — | — | US | disclosed |