Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 11/20 | 0.52 |
| ▸ | HTR1A | P08908 | 10/20 | 0.52 |
| ▸ | DRD2 | P14416 | 10/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14277643 | 0.87 | HRH3 (0.40) | DRD4HTR1ADRD2KCNH2HRH3 | |
| SCHEMBL6589456 | 0.86 | HTR1A (0.52) | DRD4HTR1ADRD2KCNH2HRH3 | |
| SCHEMBL3453460 | 0.85 | HRH3 (0.40) | DRD4HTR1ADRD2HRH3SIGMAR1 | |
| SCHEMBL6586330 | 0.84 | HTR1A (0.52) | DRD4HTR1ADRD2KCNH2HRH3 | |
| SCHEMBL6602138 | 0.82 | DRD4 (0.52) | DRD4HTR1ADRD2KCNH2HRH3 | |
| SCHEMBL3453108 | 0.82 | PPARG (0.48) | HTR1AHRH3SIGMAR1PARP1 | |
| SCHEMBL5149479 | 0.82 | HTR1A (0.53) | DRD4HTR1ADRD2KCNH2SIGMAR1 | |
| SCHEMBL3453738 | 0.80 | PPARG (0.49) | HTR1AHRH3SIGMAR1PARP1 | |
| SCHEMBL1138642 | 0.78 | DRD4 (0.52) | DRD4HTR1ADRD2KCNH2SIGMAR1 | |
| SCHEMBL14277638 | 0.78 | PARP1 (0.47) | HTR1AKCNH2HRH3SIGMAR1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7326723-B2 | Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2008-02-05 | — | — | US | claimed |
| EP-1438291-B1 | ARALKYL-TETRAHYDRO-PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI AVENTIS (FR) | 2005-09-07 | — | — | EP | claimed |
| US-20050014795-A1 | Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same | SANOFI-SYNTHELABO (FR) | 2005-01-20 | — | — | US | claimed |
| EP-1438291-A1 | ARALKYL-TETRAHYDRO-PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Sanofi-Aventis (FR) | 2004-07-21 | — | — | EP | claimed |
| WO-2003033466-A1 | ARALKYL-TETRAHYDRO-PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2003-04-24 | — | — | WO | claimed |
| US-7858824-B2 | Aralkyltetrahydropyridines, their preparation and pharmaceutical compositions containing them | SANOFI-AVENTIS (FR) | 2010-12-28 | — | — | US | disclosed |
| US-7858824-B2 | Aralkyltetrahydropyridines, their preparation and pharmaceutical compositions containing them | SANOFI-AVENTIS (FR) | 2010-12-28 | — | — | US | disclosed |
| US-20080097117-A1 | Aralkyltetrahydropyridines, Their Preparation and Pharmaceutical Compositions Containing Them | SANOFI-AVENTIS (FR) | 2008-04-24 | — | — | US | disclosed |
| US-20080097117-A1 | Aralkyltetrahydropyridines, Their Preparation and Pharmaceutical Compositions Containing Them | SANOFI-AVENTIS (FR) | 2008-04-24 | — | — | US | disclosed |
| US-7326723-B2 | Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2008-02-05 | — | — | US | disclosed |
| US-7326723-B2 | Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2008-02-05 | — | — | US | disclosed |
| EP-1438291-B1 | ARALKYL-TETRAHYDRO-PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI AVENTIS (FR) | 2005-09-07 | — | — | EP | disclosed |
| US-20050014795-A1 | Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same | SANOFI-SYNTHELABO (FR) | 2005-01-20 | — | — | US | disclosed |
| EP-1438291-A1 | ARALKYL-TETRAHYDRO-PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Sanofi-Aventis (FR) | 2004-07-21 | — | — | EP | disclosed |
| WO-2003033466-A1 | ARALKYL-TETRAHYDRO-PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2003-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014795-A1 | Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same | CYCS, NADK, CYP2F1 | DRD4 1028/4885HTR1A 1262/4885DRD2 2099/4885 |
| US-20080097117-A1 | Aralkyltetrahydropyridines, Their Preparation and Pharmaceutical Compositions Containing Them | CYP3A43, CYCS, CCNY | DRD4 429/4885HTR1A 357/4885DRD2 820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.