Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MPI | P34949 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14306707 | 0.82 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL22327923 | 0.70 | KDM4E (0.50) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL6055066 | 0.70 | KDM4E (0.50) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL6477699 | 0.68 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL14544751 | 0.68 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL11683985 | 0.68 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL14427216 | 0.68 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL5373302 | 0.67 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL8840880 | 0.67 | PDE4A (0.67) | PDE4AKDM4EHSD17B10ALDH1A1KMT2A | |
| SCHEMBL3846446 | 0.66 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080027228-A1 | Substituted thioacetamides | CEPHALON, INC. (US) | 2008-01-31 | — | — | US | disclosed |
| US-7268132-B2 | Thio substituted with a hetero multiring group; sleepiness, promotion of wakefulness, Parkinson's disease, cerebral ischemia, stroke, sleep apneas, eating disorders, stimulation of appetite and weight gain, attention deficit hyperactivity disorder | CEPHALON, INC. (US) | 2007-09-11 | — | — | US | disclosed |
| US-RE39575-E1 | Substituted thioacetamides | CEPHALON, INC. (US) | 2007-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027228-A1 | Substituted thioacetamides | TST, TTR, TBCA | PDE4A 2911/4885PDE4B 3386/4885PDE4C 2728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.