Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | PDE4A | P27815 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10220242 | 0.81 | RAB9A (0.63) | KDM4EMAPTKMT2AMEN1NPC1 | |
| SCHEMBL1662318 | 0.79 | MAPT (0.68) | KDM4EHSD17B10MAPTKMT2AMEN1 | |
| SCHEMBL22327929 | 0.78 | CDK1 (0.51) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6588583 | 0.78 | DYRK1A (0.66) | KDM4EHSD17B10MAPTKMT2AMEN1 | |
| SCHEMBL15033090 | 0.76 | SMN1; SMN2 (0.59) | KDM4EMAPTKMT2AMEN1NPC1 | |
| SCHEMBL20442996 | 0.76 | ALDH1A1 (0.46) | KDM4EHSD17B10MAPTKMT2AMEN1 | |
| SCHEMBL15425080 | 0.74 | MAPT (0.58) | KDM4EMAPTKMT2AMEN1NPC1 | |
| SCHEMBL15425096 | 0.74 | MAPT (0.77) | KDM4EMAPTKMT2AMEN1NPC1 | |
| SCHEMBL1608903 | 0.74 | MAPT (0.65) | KDM4EHSD17B10MAPTKMT2AMEN1 | |
| SCHEMBL22820479 | 0.73 | TNIK (0.50) | KMT2ASMN1; SMN2ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10800760-B2 | Trk inhibition | NANTBIO, INC. (US) | 2020-10-13 | — | — | US | disclosed |
| US-10738033-B2 | Trk inhibition | NANTBIO, INC. (US) | 2020-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10800760-B2 | Trk inhibition | NTRK1, NTRK3, NTRK2 | KDM4E 4083/4885HSD17B10 3835/4885MAPT 502/4885 |
| US-10738033-B2 | Trk inhibition | NGF, NGFR, NTRK2 | KDM4E 3735/4885HSD17B10 4160/4885MAPT 454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.