Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.47 |
| ▸ | CACNA1H | O95180 | 10/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8209942 | 0.84 | HSD11B1 (0.50) | HSD11B1CACNA1H | |
| SCHEMBL12777757 | 0.84 | HSD11B1 (0.50) | HSD11B1CACNA1H | |
| SCHEMBL14280465 | 0.76 | TRPV1 (0.55) | CACNA1HALDH1A1 | |
| SCHEMBL14280321 | 0.75 | TRPV1 (0.54) | CACNA1HALDH1A1 | |
| SCHEMBL8202443 | 0.74 | TRPV1 (0.49) | HSD11B1CACNA1HALDH1A1 | |
| SCHEMBL8201959 | 0.74 | CACNA1H (0.62) | HSD11B1CACNA1H | |
| SCHEMBL8213443 | 0.74 | CACNA1H (0.52) | HSD11B1CACNA1H | |
| SCHEMBL8209936 | 0.72 | HSD11B1 (0.50) | HSD11B1CACNA1H | |
| SCHEMBL14265972 | 0.72 | LMNA (0.38) | HSD11B1CACNA1HNPC1L1 | |
| SCHEMBL12890375 | 0.71 | SMN1; SMN2 (0.42) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033431-A1 | SPIROCYCLIC AZETIDINONE DERIVATIVES FOR THE TREATMENT OF DISORDERS OF LIPID METABOLISM, PAIN, DIABETES AND OTHER DISORDERS | SCHERING CORPORATION (US) | 2008-03-20 | — | — | WO | disclosed |