Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 13/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 8/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 2/20 | 0.40 |
| ▸ | TGFB2 | P61812 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14282426 | 0.91 | NPBWR1 (0.55) | NPBWR1MCHR1HTR2AHTR2BHTR6 | |
| SCHEMBL14282420 | 0.88 | LMNA (0.45) | NPBWR1MCHR1LMNATP53 | |
| SCHEMBL14282448 | 0.88 | CHRM3 (0.44) | NPBWR1MCHR1ADRB2DRD2HTR1D | |
| SCHEMBL14282479 | 0.88 | NPBWR1 (0.46) | NPBWR1MCHR1ALDH1A1 | |
| SCHEMBL4779571 | 0.87 | NPBWR1 (0.58) | NPBWR1MCHR1HTR2AHTR2BHTR6 | |
| SCHEMBL14282280 | 0.85 | NPBWR1 (0.53) | NPBWR1MCHR1HTR2AHTR2BHTR6 | |
| SCHEMBL14282424 | 0.84 | NPBWR1 (0.45) | NPBWR1MCHR1LTA4HCYP1A2CYP3A4 | |
| SCHEMBL14221034 | 0.83 | NPBWR1 (0.51) | NPBWR1MCHR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4649285 | 0.83 | NPBWR1 (0.53) | NPBWR1MCHR1HTR2AHTR2BHTR6 | |
| SCHEMBL14282405 | 0.82 | LMNA (0.44) | NPBWR1MCHR1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320977-B2 | Fibrotic disorders; disorders characterized by harmful buildup of collagen and/or by excessive lysyl oxidase enzymatic activity | BAYER HEALTHCARE AG (DE) | 2008-01-22 | — | — | US | disclosed |
| US-7320977-B2 | Fibrotic disorders; disorders characterized by harmful buildup of collagen and/or by excessive lysyl oxidase enzymatic activity | BAYER HEALTHCARE AG (DE) | 2008-01-22 | — | — | US | disclosed |