Alpha-Ketoglutaric Acid

Alpha-Ketoglutaric Acid

SCHEMBL1428274

O=C(O)CCC(=O)C(=O)O.[SrH2]

nearest known ligand 0.93

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 4/20 0.93
OR51E2 Q9H255 2/20 0.93
MAPK1 P28482 1/20 0.93
SLC13A3 Q8WWT9 1/20 0.93
LMNA P02545 6/20 0.60
ALKBH5 Q6P6C2 1/20 0.60
SUCNR1 Q9BXA5 1/20 0.60
SLC15A2 Q16348 1/20 0.45
SLC22A6 Q4U2R8 1/20 0.44
TSHR P16473 2/20 0.42
NFKB1 P19838 1/20 0.42
PMP22 Q01453 1/20 0.42
KDM4E B2RXH2 3/20 0.41
KDM5C P41229 3/20 0.41
PHF8 Q9UPP1 3/20 0.41
KDM2A Q9Y2K7 3/20 0.41
KDM6B O15054 2/20 0.41
FOLH1 Q04609 1/20 0.41
GABRR1 P24046 1/20 0.41
FFAR3 O14843 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Alpha-Ketoglutaric Acid SCHEMBL30208560 0.97 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL7400 0.97 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL30029036 0.97 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL932116 0.97 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL17127347 0.97 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL3776640 0.97 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL29783374 0.97 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL3184813 0.93 EGLN1 (0.93) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL1242830 0.93 EGLN1 (0.93) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL20877597 0.93 EGLN1 (0.93) EGLN1OR51E2MAPK1SLC13A3LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 111 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12636311-B2 Topically administered strontium-containing complexes for treating pain, pruritis and inflammation GALLEON LABS LLC (US) 2026-05-26 US claimed
US-20250099498-A1 STRONTIUM BASED COMPOSITIONS AND FORMULATIONS FOR PAIN, PRURITUS, AND INFLAMMATION GALLEON LABS LLC (US) 2025-03-27 US claimed
US-12121536-B2 Strontium based compositions and formulations for pain, pruritus, and inflammation GALLEON LABS LLC (US) 2024-10-22 US claimed
US-20240041919-A1 TOPICALLY ADMINISTERED STRONTIUM-CONTAINING COMPLEXES FOR TREATING PAIN, PRURITIS AND INFLAMMATION GALLEON LABS LLC 2024-02-08 US claimed
US-11801261-B2 Topically administered strontium-containing complexes for treating pain, pruritis and inflammation GALLEON LABS LLC (US) 2023-10-31 US claimed
CN-115414265-A Composition and face cream with effects of color correction, skin tendering and moisturizing and preparation method thereof 中国科学院过程工程研究所 2022-12-02 CN claimed
US-20220323485-A1 STRONTIUM BASED COMPOSITIONS AND FORMULATIONS FOR PAIN, PRURITUS, AND INFLAMMATION PIKE, JOSEPH D. 2022-10-13 US claimed
EP-2827847-B1 TOPICALLY ADMINISTERED STRONTIUM-CONTAINING COMPLEXES FOR TREATING PAIN, PRURITIS AND INFLAMMATION GALLEON LABS LLC (US) 2022-09-14 EP claimed
EP-3284462-B1 STRONTIUM BASED COMPOSITIONS AND FORMULATIONS FOR PAIN, PRURITUS, AND INFLAMMATION GALLEON LABS LLC (US) 2022-08-03 EP claimed
US-20220054535-A1 STRONTIUM BASED COMPOSITIONS AND FORMULATIONS FOR PAIN, PRURITUS, AND INFLAMMATION STRONTIUM NEUROGENICS INC (US) 2022-02-24 US claimed
EP-2266585-A2 Water-soluble strontium salts for use in treatment of cartilage and/or bone conditions Osteologix A/S (DK) 2010-12-29 EP claimed
EP-1732575-B1 STRONTIUM-CONTAINING COMPOUNDS FOR USE IN THE PREVENTION OR TREATMENT OF NECROTIC BONE CONDITIONS OSTEOLOGIX AS (DK) 2010-12-29 EP claimed
EP-1768748-B1 COMPOSITIONS COMPRISING STRONTIUM AND VITAMIN D AND USES THEREOF STRONTIN APS (DK) 2009-09-23 EP claimed
US-20080260714-A1 Nutrient mixture comprising fibrin, thrombin and a strontium-containing compound for use as therapeutic in bone healing or bone growth BAXTER INTERNATIONAL INC. (US) 2008-10-23 US claimed
US-20080167513-A1 Strontium-Containing Compounds for Use in the Prevention or Treatment of Necrotic Bone Conditions OSTEOLOGLX A/S (DK) 2008-07-10 US claimed
EP-1732575-A1 STRONTIUM-CONTAINING COMPOUNDS FOR USE IN THE PREVENTION OR TREATMENT OF NECROTIC BONE CONDITIONS Osteologix A/S (DK) 2006-12-20 EP claimed
US-20060122274-A1 Water-soluble strontium salts for use in treatment of cartilage and/or bone conditions OSTEOLOGIX A/S (DK) 2006-06-08 US claimed
WO-2005082385-A1 STRONTIUM-CONTAINING COMPOUNDS FOR USE IN THE PREVENTION OR TREATMENT OF NECROTIC BONE CONDITIONS OSTEOLOGIX A/S (DK) 2005-09-09 WO claimed
EP-1534305-A2 TREATING CARTILAGE / BONE CONDITIONS WITH WATER-SOLUBLE STRONTIUM SALTS Osteologix A/S (DK) 2005-06-01 EP claimed
WO-2004098619-A2 TREATING CARTILAGE / BONE CONDITIONS WITH WATER-SOLUBLE STRONTIUM SALTS OSTEOLOGIX A/S (DK) 2004-11-18 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12636311-B2 Topically administered strontium-containing complexes for treating pain, pruritis and inflammation SUCNR1, TRPV1, TRPV2 EGLN1 770/4885OR51E2 3212/4885MAPK1 1242/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.