SCHEMBL14282940

SCHEMBL14282940

CCOC(=O)CCN1CCC(C(c2ccccc2)c2ccccc2)CC1

nearest known ligand 0.52

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.52
KDM4E B2RXH2 2/20 0.52
PRCP P42785 1/20 0.51
NPY2R P49146 1/20 0.50
THRB P10828 1/20 0.48
LMNA P02545 1/20 0.47
EGFR P00533 2/20 0.47
KMT2A Q03164 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
MAPT P10636 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4072745 0.90 PRCP (0.49) ALDH1A1KDM4EPRCPNPY2RTHRB
SCHEMBL4695183 0.88 PRCP (0.52) KDM4EPRCP
SCHEMBL4253158 0.88 PRCP (0.55) ALDH1A1KDM4EPRCPNPY2R
SCHEMBL14282927 0.87 BACE1 (0.52) ALDH1A1KDM4ENPY2RLMNA
SCHEMBL4254317 0.84 BCHE (0.59) LMNAEGFR
SCHEMBL12123733 0.84 PRCP (0.55) KDM4EPRCP
SCHEMBL14282941 0.84 PRCP (0.54) KDM4EPRCPLMNA
Hydrochloric Acid SCHEMBL9356588 0.83 BCHE (0.58) ALDH1A1THRBLMNAEGFRKMT2A
SCHEMBL9353361 0.83 KDM4E (0.46) ALDH1A1KDM4EPRCPTHRBLMNA
Hydrochloric Acid SCHEMBL9352843 0.82 ALDH1A1 (0.45) ALDH1A1KDM4EPRCPTHRBLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7317026-B2 Sleep disorders; side effect reduction ; antihistamine antagonist HYPNION, INC. (US) 2008-01-08 US disclosed