Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 0.58 |
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.58 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.58 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.58 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.58 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.58 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.58 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.58 |
| ▸ | HTR3A known ✓ | P46098 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | DRD2 | P14416 | 3/20 | 0.58 |
| ▸ | DRD1 | P21728 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | DRD4 | P21917 | 2/20 | 0.58 |
| ▸ | DRD5 | P21918 | 2/20 | 0.58 |
| ▸ | DRD3 | P35462 | 2/20 | 0.58 |
| ▸ | RECQL | P46063 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL113163 | 0.98 | TAAR1 (0.60) | TAAR1MAPK1KDM4EADRA2ASLC6A2 | |
| SCHEMBL11669534 | 0.84 | BACE1 (0.57) | TAAR1MAPK1KDM4EADRA2ASLC6A2 | |
| SCHEMBL8173017 | 0.82 | KDM4E (0.40) | TAAR1MAPK1KDM4EADRA2ASLC6A2 | |
| SCHEMBL28873594 | 0.79 | CA2 (0.53) | CA12CA1CA2CA4CA6 | |
| SCHEMBL111618 | 0.79 | CA12 (0.52) | TAAR1MAPK1KDM4EADRA2ASLC6A2 | |
| SCHEMBL3769908 | 0.79 | CA12 (0.52) | TAAR1MAPK1KDM4EADRA2ASLC6A2 | |
| Dopamine SCHEMBL3114891 | 0.78 | KDM4E (0.81) | TAAR1MAPK1KDM4EADRA2ASLC6A2 | |
| Dopamine SCHEMBL9241925 | 0.78 | KDM4E (0.81) | TAAR1MAPK1KDM4EADRA2ASLC6A2 | |
| Dopamine SCHEMBL30960386 | 0.77 | KDM4E (0.95) | TAAR1MAPK1KDM4EADRA2ASLC6A2 | |
| Dopamine SCHEMBL3769932 | 0.77 | KDM4E (0.95) | TAAR1MAPK1KDM4EADRA2ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058984-A1 | PYRIMIDINE DERIVATIVES USED AS ITK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | US | disclosed |
| EP-2408769-A1 | PYRIMIDINE DERIVATIVES USED AS ITK INHIBITORS | Glaxo Group Limited (GB) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010106016-A1 | PYRIMIDINE DERIVATIVES USED AS ITK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2010-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058984-A1 | PYRIMIDINE DERIVATIVES USED AS ITK INHIBITORS | DTYMK, ITK, DCK | ADRA2A 4644/4885SLC6A2 3554/4885SLC6A3 3822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.