Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | ATP4A | P20648 | 2/20 | 0.38 |
| ▸ | ATP4B | P51164 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14600770 | 0.79 | HRH4 (0.36) | HPGDCYP11B1CYP11B2ALDH1A1F2 | |
| SCHEMBL14286147 | 0.78 | MAPK1 (0.37) | MAPK1MAPK10HPGDALDH1A1HTT | |
| SCHEMBL14286148 | 0.71 | MAPK1 (0.42) | MAPK1MAPK10ATP4AATP4BHPGD | |
| SCHEMBL5037079 | 0.70 | KCNN4 (0.40) | ALDH1A1 | |
| SCHEMBL14286151 | 0.69 | ADORA2A (0.39) | MAPK1MAPK10 | |
| SCHEMBL5038382 | 0.68 | MAPK1 (0.49) | MAPK1MAPK10ATP4AATP4BHPGD | |
| SCHEMBL10067969 | 0.68 | HRH4 (0.35) | HPGDALDH1A1HTTF2F10 | |
| SCHEMBL14286171 | 0.68 | MAPK1 (0.52) | MAPK1MAPK10ATP4AATP4BHPGD | |
| SCHEMBL5047846 | 0.66 | MAPK1 (0.47) | MAPK1MAPK10ATP4AATP4BHPGD | |
| SCHEMBL14286136 | 0.65 | MAPK1 (0.44) | MAPK1MAPK10ATP4AATP4BHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7314885-B2 | Pyrrole compounds useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-01-01 | — | — | US | disclosed |
| US-7314885-B2 | Pyrrole compounds useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-01-01 | — | — | US | disclosed |