Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 2/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14286147 | 0.80 | MAPK1 (0.37) | HPGDGRIN2BHTTSMN1; SMN2CYP2D6 | |
| SCHEMBL14600770 | 0.78 | HRH4 (0.36) | HRH4HPGDLMNAF10F2 | |
| SCHEMBL14286149 | 0.68 | MAPK1 (0.41) | HRH4HPGDHTTLMNAF10 | |
| SCHEMBL14600761 | 0.63 | HPGD (0.42) | HRH4HPGDSMN1; SMN2CYP2C9CYP2C19 | |
| SCHEMBL986040 | 0.61 | KCNN4 (0.40) | HPGDSMN1; SMN2LMNANPSR1F10 | |
| SCHEMBL5042176 | 0.61 | ALDH1A1 (0.39) | HTTCYP2D6CYP2C9CYP2C19LMNA | |
| SCHEMBL14600754 | 0.61 | HPGD (0.42) | HRH4HPGDGRIN2BSMN1; SMN2LMNA | |
| SCHEMBL14600760 | 0.59 | HPGD (0.42) | HRH4HPGDSMN1; SMN2CYP2C9CYP2C19 | |
| SCHEMBL8711475 | 0.57 | RAB9A (0.45) | HPGDGRIN2BSMN1; SMN2ALDH1A1KCNN4 | |
| SCHEMBL28921681 | 0.54 | ALDH1A1 (0.62) | GRIN2BHTTSMN1; SMN2LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697352-B1 | 4-AZOLE SUBSTITUTED IMIDAZOLE COMPOSITIONS USEFUL AS INHIBITORS OR C-MET RECEPTOR TYROSINE KINASE | VERTEX PHARMA (US) | 2012-06-27 | — | — | EP | disclosed |
| US-7169800-B2 | Imidazole compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-01-30 | — | — | US | disclosed |