Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Alazanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 1.00 |
| ▸ | NPC1 | O15118 | 5/20 | 1.00 |
| ▸ | RAB9A | P51151 | 5/20 | 1.00 |
| ▸ | APAF1 | O14727 | 2/20 | 1.00 |
| ▸ | ITGB2 | P05107 | 1/20 | 1.00 |
| ▸ | ALPL | P05186 | 1/20 | 1.00 |
| ▸ | ITGAM | P11215 | 1/20 | 1.00 |
| ▸ | GFER | P55789 | 1/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 6/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.98 |
| ▸ | HTT | P42858 | 5/20 | 0.98 |
| ▸ | BLM | P54132 | 4/20 | 0.98 |
| ▸ | MAPT | P10636 | 3/20 | 0.92 |
| ▸ | THRB | P10828 | 3/20 | 0.92 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.92 |
| ▸ | POLB | P06746 | 2/20 | 0.92 |
| ▸ | PKM | P14618 | 2/20 | 0.92 |
| ▸ | RECQL | P46063 | 2/20 | 0.92 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.92 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alazanine SCHEMBL5453750 | 1.00 | APP (1.00) | APPNPC1RAB9AAPAF1ITGB2 | |
| Alazanine SCHEMBL29556313 | 1.00 | APP (1.00) | APPNPC1RAB9AAPAF1ITGB2 | |
| Alazanine SCHEMBL26664759 | 1.00 | APP (1.00) | APPNPC1RAB9AAPAF1ITGB2 | |
| Alazanine SCHEMBL29887077 | 1.00 | APP (1.00) | APPNPC1RAB9AAPAF1ITGB2 | |
| Alazanine SCHEMBL26664756 | 1.00 | APP (1.00) | APPNPC1RAB9AAPAF1ITGB2 | |
| Alazanine SCHEMBL30133356 | 0.99 | MEN1 (1.00) | APPNPC1RAB9AAPAF1ITGB2 | |
| Alazanine SCHEMBL1506901 | 0.99 | MEN1 (1.00) | APPNPC1RAB9AAPAF1ITGB2 | |
| Alazanine SCHEMBL10020546 | 0.99 | MEN1 (1.00) | APPNPC1RAB9AAPAF1ITGB2 | |
| Alazanine SCHEMBL12364489 | 0.99 | MEN1 (1.00) | APPNPC1RAB9AAPAF1ITGB2 | |
| Alazanine SCHEMBL1506900 | 0.99 | MEN1 (1.00) | APPNPC1RAB9AAPAF1ITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 434 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3120392-A1 | TRANSPARENT ENERGY-HARVESTING DEVICES | Board of Trustees of Michigan State University (US) | 2017-01-25 | — | — | EP | claimed |
| US-20150301058-A1 | BIOMARKER COMPOSITIONS AND METHODS | CARIS LIFE SCIENCES SWITZERLAND HOLDINGS GMBH (CH) | 2015-10-22 | — | — | US | claimed |
| EP-2922861-A1 | BIOMARKER COMPOSITIONS AND METHODS | Caris Science Inc. (US) | 2015-09-30 | — | — | EP | claimed |
| WO-2015143038-A1 | TRANSPARENT ENERGY-HARVESTING DEVICES | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2015-09-24 | — | — | WO | claimed |
| US-20140283896-A1 | Transparent Energy-Harvesting Devices | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2014-09-25 | — | — | US | claimed |
| US-20140154614-A1 | METHOD FOR PREPARING COLORFUL THREE-DIMENSIONAL HOLOGRAM BASED ON HOLOGRAPHIC POLYMER DISPERSED LIQUID CRYSTAL GRATING | HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2014-06-05 | — | — | US | claimed |
| WO-2014082083-A1 | BIOMARKER COMPOSITIONS AND METHODS | CARIS SCIENCE, INC. (US) | 2014-05-30 | — | — | WO | claimed |
| EP-1631677-B1 | SYSTEM FOR DETECTING POLYNUCLEOTIDES | INVESTIGEN INC (US) | 2010-11-17 | — | — | EP | claimed |
| WO-2010101649-A2 | SIGMA 1 RECEPTOR INHIBITION AS A NOVEL THERAPEUTICAL APPROACH AGAINST HEPATITIS C VIRUS INFECTION | GASTAMINZA PABLO (US) | 2010-09-10 | — | — | WO | claimed |
| US-7745119-B2 | System for detecting polynucleotides | INVESTIGEN, INC. (US) | 2010-06-29 | — | — | US | claimed |
| EP-1631677-A2 | SYSTEM FOR DETECTING POLYNUCLEOTIDES | Investigen, Inc. (US) | 2006-03-08 | — | — | EP | claimed |
| WO-2005017181-A2 | SYSTEM FOR DETECTING POLYNUCLEOTIDES | INVESTIGEN, INC. (US) | 2005-02-24 | — | — | WO | claimed |
| US-6538725-B2 | Method for determination of structural defects of coatings | GENERAL ELECTRIC COMPANY | 2003-03-25 | — | — | US | claimed |
| US-20020135758-A1 | Method for determination of structural defects of coatings | GENERAL ELECTRIC COMPANY | 2002-09-26 | — | — | US | claimed |
| US-6342329-B1 | Image-forming medium | BROTHER KOGYO KABUSHIKI KAISHA (JP) | 2002-01-29 | — | — | US | claimed |
| US-20010045529-A1 | Double-resonance-absorption microscope | OLYMPUS CORPORATION (JP) | 2001-11-29 | — | — | US | claimed |
| WO-2000030632-A1 | ARYL AND HETEROARYL COMPOUNDS USEFUL AS FIBROBLAST GROWTH FACTOR ANTAGONISTS | EISAI CO., LTD. (JP) | 2000-06-02 | — | — | WO | claimed |
| EP-0930539-A1 | Image-forming medium | BROTHER KOGYO KABUSHIKI KAISHA (JP) | 1999-07-21 | — | — | EP | claimed |
| US-4728796-A | Method for ionization of polymers | MEDICAL COLLEGE OF WISCONSIN (US) | 1988-03-01 | — | — | US | claimed |
| US-4232552-A | THERMOCHROMISM, DISPOSABLE THERMOMETERS | AKZONA INCORPORATED (US) | 1980-11-11 | — | — | US | claimed |